Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.

Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.

In mammals, male sex determination is governed by SRY-dependent activation of Sox9, whereas female development involves R-spondin1 (RSPO1), an activator of the WNT/beta-catenin signaling pathway. Genetic analyses in mice have demonstrated Sry and Sox9 to be both required and sufficient to induce tes...

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Main Authors: Rowena Lavery, Anne-Amandine Chassot, Eva Pauper, Elodie P Gregoire, Muriel Klopfenstein, Dirk G de Rooij, Manuel Mark, Andreas Schedl, Norbert B Ghyselinck, Marie-Christine Chaboissier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003170&type=printable
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