Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart?
After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase o...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/817364 |
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| _version_ | 1832567328115523584 |
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| author | Pablo Díez Villanueva Ricardo Sanz-Ruiz Alberto Núñez García María Eugenia Fernández Santos Pedro L. Sánchez Francisco Fernández-Avilés |
| author_facet | Pablo Díez Villanueva Ricardo Sanz-Ruiz Alberto Núñez García María Eugenia Fernández Santos Pedro L. Sánchez Francisco Fernández-Avilés |
| author_sort | Pablo Díez Villanueva |
| collection | DOAJ |
| description | After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease, and several efficacy phase III trials with clinical endpoints are on their way. Nevertheless, a complete knowledge on the mechanisms of action of stem cells still remains elusive. Of the three main mechanisms by which stem cells could exert their benefit, paracrine signaling from the administered cells and stimulation of endogenous repair are nowadays the most plausible ones. However, in this review we will define and discuss the concept of stem cell potency and differentiation, will examine the evidence available, and will depict future directions of research. |
| format | Article |
| id | doaj-art-acb9778590044e18ace18cd21c69ec18 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-acb9778590044e18ace18cd21c69ec182025-02-03T01:01:51ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/817364817364Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart?Pablo Díez Villanueva0Ricardo Sanz-Ruiz1Alberto Núñez García2María Eugenia Fernández Santos3Pedro L. Sánchez4Francisco Fernández-Avilés5Cardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainAfter more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease, and several efficacy phase III trials with clinical endpoints are on their way. Nevertheless, a complete knowledge on the mechanisms of action of stem cells still remains elusive. Of the three main mechanisms by which stem cells could exert their benefit, paracrine signaling from the administered cells and stimulation of endogenous repair are nowadays the most plausible ones. However, in this review we will define and discuss the concept of stem cell potency and differentiation, will examine the evidence available, and will depict future directions of research.http://dx.doi.org/10.1155/2012/817364 |
| spellingShingle | Pablo Díez Villanueva Ricardo Sanz-Ruiz Alberto Núñez García María Eugenia Fernández Santos Pedro L. Sánchez Francisco Fernández-Avilés Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? Stem Cells International |
| title | Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? |
| title_full | Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? |
| title_fullStr | Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? |
| title_full_unstemmed | Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? |
| title_short | Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? |
| title_sort | functional multipotency of stem cells what do we need from them in the heart |
| url | http://dx.doi.org/10.1155/2012/817364 |
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