Precursors to Cholangiocarcinoma
Cancers of the biliary tract include intra- and extrahepatic cholangiocarcinomas and gallbladder cancer. Biliary tract cancers are diseases with unfavorable prognoses. In recent years, several lesions have been described as precursors that precede biliary cancers. They include flat and microscopic l...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/1389289 |
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| _version_ | 1832560962284027904 |
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| author | Tomas Hucl |
| author_facet | Tomas Hucl |
| author_sort | Tomas Hucl |
| collection | DOAJ |
| description | Cancers of the biliary tract include intra- and extrahepatic cholangiocarcinomas and gallbladder cancer. Biliary tract cancers are diseases with unfavorable prognoses. In recent years, several lesions have been described as precursors that precede biliary cancers. They include flat and microscopic lesions known as biliary intraepithelial neoplasia, macroscopic and tumor-forming intraductal papillary biliary neoplasia, intraductal tubular neoplasia, and mucinous cystic neoplasm of the bile duct. These conditions are rarely diagnosed, while their natural history and progression to cancer have yet to be adequately characterized. This review examines the epidemiology, pathology, molecular biology, diagnosis, and therapy of these various precursors. Further research is required if we are to better understand this evolving field and improve the prevention and early detection of bile duct cancer. |
| format | Article |
| id | doaj-art-aca4a111cbb649d2a83a741eab759867 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-aca4a111cbb649d2a83a741eab7598672025-02-03T01:26:21ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/13892891389289Precursors to CholangiocarcinomaTomas Hucl0Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech RepublicCancers of the biliary tract include intra- and extrahepatic cholangiocarcinomas and gallbladder cancer. Biliary tract cancers are diseases with unfavorable prognoses. In recent years, several lesions have been described as precursors that precede biliary cancers. They include flat and microscopic lesions known as biliary intraepithelial neoplasia, macroscopic and tumor-forming intraductal papillary biliary neoplasia, intraductal tubular neoplasia, and mucinous cystic neoplasm of the bile duct. These conditions are rarely diagnosed, while their natural history and progression to cancer have yet to be adequately characterized. This review examines the epidemiology, pathology, molecular biology, diagnosis, and therapy of these various precursors. Further research is required if we are to better understand this evolving field and improve the prevention and early detection of bile duct cancer.http://dx.doi.org/10.1155/2019/1389289 |
| spellingShingle | Tomas Hucl Precursors to Cholangiocarcinoma Gastroenterology Research and Practice |
| title | Precursors to Cholangiocarcinoma |
| title_full | Precursors to Cholangiocarcinoma |
| title_fullStr | Precursors to Cholangiocarcinoma |
| title_full_unstemmed | Precursors to Cholangiocarcinoma |
| title_short | Precursors to Cholangiocarcinoma |
| title_sort | precursors to cholangiocarcinoma |
| url | http://dx.doi.org/10.1155/2019/1389289 |
| work_keys_str_mv | AT tomashucl precursorstocholangiocarcinoma |