Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

<h4>Background</h4>Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident AF is limited. We investigated...

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Main Authors: J E Siland, B Geelhoed, C Roselli, B Wang, H J Lin, S Weiss, S Trompet, M E van den Berg, E Z Soliman, L Y Chen, I Ford, J W Jukema, P W Macfarlane, J Kornej, H Lin, K L Lunetta, M Kavousi, J A Kors, M A Ikram, X Guo, J Yao, M Dörr, S B Felix, U Völker, N Sotoodehnia, D E Arking, B H Stricker, S R Heckbert, S A Lubitz, E J Benjamin, A Alonso, P T Ellinor, P van der Harst, M Rienstra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268768&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268768&type=printable

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