Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels
Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2022/4559809 |
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| author | Jinshan He Sicong Li Yumeng Ding Yujia Tong Xuebin Li |
| author_facet | Jinshan He Sicong Li Yumeng Ding Yujia Tong Xuebin Li |
| author_sort | Jinshan He |
| collection | DOAJ |
| description | Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed. Active components extracted from natural products are potential choices for AF therapy. Natural products like Panax notoginseng (Burk.) F.H. Chen, Sophora flavescens Ait., Stephania tetrandra S. Moore., Pueraria lobata (Willd.) Ohwi var. thomsonii (Benth.) Vaniot der Maesen., and Coptis chinensis Franch. have a long history in the treatment of arrhythmia, myocardial infarction, stroke, and heart failure in China. Based on the classification of chemical structures, this article discussed the natural product components’ therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes, in order to provide a reference for development of therapeutic drugs for atrial fibrillation. |
| format | Article |
| id | doaj-art-ac92e06447fe45a1a598249d41f8f786 |
| institution | Kabale University |
| issn | 1755-5922 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-ac92e06447fe45a1a598249d41f8f7862025-02-03T06:01:52ZengWileyCardiovascular Therapeutics1755-59222022-01-01202210.1155/2022/4559809Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion ChannelsJinshan He0Sicong Li1Yumeng Ding2Yujia Tong3Xuebin Li4Cardiovascular DepartmentSchool of PharmacySchool of Life SciencesInstitute of Medical InformationCardiovascular DepartmentAntiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed. Active components extracted from natural products are potential choices for AF therapy. Natural products like Panax notoginseng (Burk.) F.H. Chen, Sophora flavescens Ait., Stephania tetrandra S. Moore., Pueraria lobata (Willd.) Ohwi var. thomsonii (Benth.) Vaniot der Maesen., and Coptis chinensis Franch. have a long history in the treatment of arrhythmia, myocardial infarction, stroke, and heart failure in China. Based on the classification of chemical structures, this article discussed the natural product components’ therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes, in order to provide a reference for development of therapeutic drugs for atrial fibrillation.http://dx.doi.org/10.1155/2022/4559809 |
| spellingShingle | Jinshan He Sicong Li Yumeng Ding Yujia Tong Xuebin Li Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels Cardiovascular Therapeutics |
| title | Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels |
| title_full | Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels |
| title_fullStr | Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels |
| title_full_unstemmed | Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels |
| title_short | Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels |
| title_sort | research progress on natural products therapeutic effects on atrial fibrillation by regulating ion channels |
| url | http://dx.doi.org/10.1155/2022/4559809 |
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