Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus
Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses. We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/2979486 |
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| _version_ | 1832559506816499712 |
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| author | Kara A. Bjur Bryan C. Cannon Anthony L. Fine Matthew J. Ritter Kerry E. Schueler Michael E. Nemergut |
| author_facet | Kara A. Bjur Bryan C. Cannon Anthony L. Fine Matthew J. Ritter Kerry E. Schueler Michael E. Nemergut |
| author_sort | Kara A. Bjur |
| collection | DOAJ |
| description | Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses. We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated with multiple PG-containing medications (lorazepam, phenobarbital, and pentobarbital)—all within accepted dosing guidelines and a total daily PG exposure previously recognized to be safe. Hemodynamic measurements by bedside echocardiography during clinical toxicity are also reported. Clinicians should have a high index of suspicion for propylene glycol toxicity in patients treated with PG-containing medications even when the total PG exposure is lower than currently accepted limits. |
| format | Article |
| id | doaj-art-ac842818e58144c08045425b18d135b0 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-ac842818e58144c08045425b18d135b02025-02-03T01:29:55ZengWileyCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/29794862979486Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status EpilepticusKara A. Bjur0Bryan C. Cannon1Anthony L. Fine2Matthew J. Ritter3Kerry E. Schueler4Michael E. Nemergut5Mayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAPropylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses. We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated with multiple PG-containing medications (lorazepam, phenobarbital, and pentobarbital)—all within accepted dosing guidelines and a total daily PG exposure previously recognized to be safe. Hemodynamic measurements by bedside echocardiography during clinical toxicity are also reported. Clinicians should have a high index of suspicion for propylene glycol toxicity in patients treated with PG-containing medications even when the total PG exposure is lower than currently accepted limits.http://dx.doi.org/10.1155/2017/2979486 |
| spellingShingle | Kara A. Bjur Bryan C. Cannon Anthony L. Fine Matthew J. Ritter Kerry E. Schueler Michael E. Nemergut Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus Case Reports in Pediatrics |
| title | Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus |
| title_full | Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus |
| title_fullStr | Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus |
| title_full_unstemmed | Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus |
| title_short | Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus |
| title_sort | propylene glycol toxicity in adolescent with refractory myoclonic status epilepticus |
| url | http://dx.doi.org/10.1155/2017/2979486 |
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