Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
Liver disease is a severe health problem that endangers human health worldwide. Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials havi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/5513309 |
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| _version_ | 1832567956292239360 |
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| author | Shan-jing Xu Li-ping Ye Wei Wang Ya-hong Chen Jian Dong Xin-li Mao Shao-wei Li |
| author_facet | Shan-jing Xu Li-ping Ye Wei Wang Ya-hong Chen Jian Dong Xin-li Mao Shao-wei Li |
| author_sort | Shan-jing Xu |
| collection | DOAJ |
| description | Liver disease is a severe health problem that endangers human health worldwide. Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials having confirmed the considerable efficacy of MSC therapy in liver diseases, the questionable safety and efficacy still limit its application. As a precursor cell, MSCs can adjust their characteristics in response to the surrounding microenvironment. The microenvironment provides physical and chemical factors essential for stem cell survival, proliferation, and differentiation. However, the mechanisms are still not completely understood. We, therefore, summarized the mechanisms underlying the MSC immune response, especially the interaction between MSCs and the liver microenvironment, discussing how to achieve better therapeutic effects. |
| format | Article |
| id | doaj-art-ac7d028edac647b7883ba82f69d87287 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ac7d028edac647b7883ba82f69d872872025-02-03T01:00:07ZengWileyStem Cells International1687-96782021-01-01202110.1155/2021/5513309Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver DiseasesShan-jing Xu0Li-ping Ye1Wei Wang2Ya-hong Chen3Jian Dong4Xin-li Mao5Shao-wei Li6Shaoxing University School of MedicineKey Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang ProvinceTaizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityHealth Management CenterTianjin Key Laboratory of Information Sensing & Intelligent ControlShaoxing University School of MedicineKey Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang ProvinceLiver disease is a severe health problem that endangers human health worldwide. Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials having confirmed the considerable efficacy of MSC therapy in liver diseases, the questionable safety and efficacy still limit its application. As a precursor cell, MSCs can adjust their characteristics in response to the surrounding microenvironment. The microenvironment provides physical and chemical factors essential for stem cell survival, proliferation, and differentiation. However, the mechanisms are still not completely understood. We, therefore, summarized the mechanisms underlying the MSC immune response, especially the interaction between MSCs and the liver microenvironment, discussing how to achieve better therapeutic effects.http://dx.doi.org/10.1155/2021/5513309 |
| spellingShingle | Shan-jing Xu Li-ping Ye Wei Wang Ya-hong Chen Jian Dong Xin-li Mao Shao-wei Li Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases Stem Cells International |
| title | Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases |
| title_full | Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases |
| title_fullStr | Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases |
| title_full_unstemmed | Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases |
| title_short | Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases |
| title_sort | role of the microenvironment in mesenchymal stem cell based strategies for treating human liver diseases |
| url | http://dx.doi.org/10.1155/2021/5513309 |
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