Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture
The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5-...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000614 |
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| _version_ | 1832560890557235200 |
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| author | C. Zoja A. Benigni G. Piccinini M. Figliuzzi L. Longaretti G. Remuzzi |
| author_facet | C. Zoja A. Benigni G. Piccinini M. Figliuzzi L. Longaretti G. Remuzzi |
| author_sort | C. Zoja |
| collection | DOAJ |
| description | The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis. |
| format | Article |
| id | doaj-art-ac76a2d39ebe45b698ef4c25dd6cfa8c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ac76a2d39ebe45b698ef4c25dd6cfa8c2025-02-03T01:26:30ZengWileyMediators of Inflammation0962-93511466-18611993-01-012642943310.1155/S0962935193000614Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in cultureC. Zoja0A. Benigni1G. Piccinini2M. Figliuzzi3L. Longaretti4G. Remuzzi5Mario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, ItalyMario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, ItalyMario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, ItalyMario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, ItalyMario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, ItalyMario Negri Institute for Pharmacological Research, via Gavazzeni 11, Bergamo, ItalyThe effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.http://dx.doi.org/10.1155/S0962935193000614 |
| spellingShingle | C. Zoja A. Benigni G. Piccinini M. Figliuzzi L. Longaretti G. Remuzzi Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture Mediators of Inflammation |
| title | Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| title_full | Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| title_fullStr | Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| title_full_unstemmed | Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| title_short | Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| title_sort | interleukin 6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture |
| url | http://dx.doi.org/10.1155/S0962935193000614 |
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