LncRNAs: New Players in Apoptosis Control
The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators invol...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/473857 |
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| _version_ | 1832548420146954240 |
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| author | Marianna Nicoletta Rossi Fabrizio Antonangeli |
| author_facet | Marianna Nicoletta Rossi Fabrizio Antonangeli |
| author_sort | Marianna Nicoletta Rossi |
| collection | DOAJ |
| description | The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. We discuss the new perspectives of using lncRNAs as targets of anticancer drugs. Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers. |
| format | Article |
| id | doaj-art-ac6f7a98ff9b453683e4f56c4e5e6cb1 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-ac6f7a98ff9b453683e4f56c4e5e6cb12025-02-03T06:14:09ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/473857473857LncRNAs: New Players in Apoptosis ControlMarianna Nicoletta Rossi0Fabrizio Antonangeli1Pasteur Institute-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyPasteur Institute-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, ItalyThe discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. We discuss the new perspectives of using lncRNAs as targets of anticancer drugs. Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers.http://dx.doi.org/10.1155/2014/473857 |
| spellingShingle | Marianna Nicoletta Rossi Fabrizio Antonangeli LncRNAs: New Players in Apoptosis Control International Journal of Cell Biology |
| title | LncRNAs: New Players in Apoptosis Control |
| title_full | LncRNAs: New Players in Apoptosis Control |
| title_fullStr | LncRNAs: New Players in Apoptosis Control |
| title_full_unstemmed | LncRNAs: New Players in Apoptosis Control |
| title_short | LncRNAs: New Players in Apoptosis Control |
| title_sort | lncrnas new players in apoptosis control |
| url | http://dx.doi.org/10.1155/2014/473857 |
| work_keys_str_mv | AT mariannanicolettarossi lncrnasnewplayersinapoptosiscontrol AT fabrizioantonangeli lncrnasnewplayersinapoptosiscontrol |