Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer
Background Small cell lung cancer is sensitive to chemotherapy and radiotherapy, but local recurrence and distant metastasis occur shortly after treatment. This study aimed to evaluate the real-world value of anlotinib as a maintenance therapy in patients with extensive-stage small cell lung cancer...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-01-01
|
| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338251317571 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576008327266304 |
|---|---|
| author | Jinbo Ma MD Xiaoyan Ma MS Wei Zhang MD Shanliang Hu MS Rukun Zang MS Xiaolong Wu MS Jie Song MD |
| author_facet | Jinbo Ma MD Xiaoyan Ma MS Wei Zhang MD Shanliang Hu MS Rukun Zang MS Xiaolong Wu MS Jie Song MD |
| author_sort | Jinbo Ma MD |
| collection | DOAJ |
| description | Background Small cell lung cancer is sensitive to chemotherapy and radiotherapy, but local recurrence and distant metastasis occur shortly after treatment. This study aimed to evaluate the real-world value of anlotinib as a maintenance therapy in patients with extensive-stage small cell lung cancer (ES-SCLC) after first-line chemotherapy and consolidative thoracic radiotherapy (CTRT). Patients and Methods A total of 150 patients with ES-SCLC treated with first-line chemotherapy and CTRT from April 2017 to December 2021 were retrospectively analyzed. After the completion of chemoradiotherapy, patients received anlotinib according to their desire. The primary endpoints were progression-free survival (PFS) and overall survival (OS) after the first diagnosis, and the secondary endpoints were prognostic factors and safety. Results The ORR and DCR of patients with ES-SCLC were 50.0% and 80.3%, respectively, in the anlotinib group and 42.9% and 69.0% in the no-maintenance therapy group. The 3-year OS rates were 27.6% and 12.6% in the anlotinib and observation groups (HR = 2.52, P = 0.003), and the median OS times were 23.8 months and 15.3 months. The 3-year PFS rates were 18.2% and 8.8% in the anlotinib and observation groups (HR = 1.76, P = 0.034) with median PFS times of 11.5 months and 8.8 months. After stratification on the basis of clinical response, patients who achieved CR plus PR after chemoradiotherapy had a longer median OS in the anlotinib and observation groups (34.0 months vs 24.8 months, HR = 2.40, P = 0.009). There were higher incidence rates of hand–foot syndrome (27.3% vs 10.5%, P = 0.001), gingival bleeding/hemoptysis (18.5% vs 4.8%, P = 0.015) and rash (33.3% vs 4.8%, P < 0.001) in the anlotinib group than in the observation group. Conclusion Maintenance therapy with anlotinib improved the survival of patients with ES-SCLC after first-line chemotherapy and CTRT. Owing to the small sample size of the real-world trial, the reliability of our study needs to be confirmed in more studies. |
| format | Article |
| id | doaj-art-ac6c5c8eff3046e681a27b69061a2405 |
| institution | Kabale University |
| issn | 1533-0338 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj-art-ac6c5c8eff3046e681a27b69061a24052025-01-31T15:04:03ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382025-01-012410.1177/15330338251317571Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung CancerJinbo Ma MD0Xiaoyan Ma MS1Wei Zhang MD2Shanliang Hu MS3Rukun Zang MS4Xiaolong Wu MS5Jie Song MD6 Department of Radiation Oncology, , Yantai, P.R. China Department of Radiation Oncology, , Yantai, P.R. China Department of Radiation Oncology, , Yantai, P.R. China Department of Radiation Oncology, , Yantai, P.R. China Department of Radiation Oncology, , Yantai, P.R. China Department of Radiation Oncology, , Yantai, P.R. China Department of Respiratory Medicine, , Yantai, P.R. ChinaBackground Small cell lung cancer is sensitive to chemotherapy and radiotherapy, but local recurrence and distant metastasis occur shortly after treatment. This study aimed to evaluate the real-world value of anlotinib as a maintenance therapy in patients with extensive-stage small cell lung cancer (ES-SCLC) after first-line chemotherapy and consolidative thoracic radiotherapy (CTRT). Patients and Methods A total of 150 patients with ES-SCLC treated with first-line chemotherapy and CTRT from April 2017 to December 2021 were retrospectively analyzed. After the completion of chemoradiotherapy, patients received anlotinib according to their desire. The primary endpoints were progression-free survival (PFS) and overall survival (OS) after the first diagnosis, and the secondary endpoints were prognostic factors and safety. Results The ORR and DCR of patients with ES-SCLC were 50.0% and 80.3%, respectively, in the anlotinib group and 42.9% and 69.0% in the no-maintenance therapy group. The 3-year OS rates were 27.6% and 12.6% in the anlotinib and observation groups (HR = 2.52, P = 0.003), and the median OS times were 23.8 months and 15.3 months. The 3-year PFS rates were 18.2% and 8.8% in the anlotinib and observation groups (HR = 1.76, P = 0.034) with median PFS times of 11.5 months and 8.8 months. After stratification on the basis of clinical response, patients who achieved CR plus PR after chemoradiotherapy had a longer median OS in the anlotinib and observation groups (34.0 months vs 24.8 months, HR = 2.40, P = 0.009). There were higher incidence rates of hand–foot syndrome (27.3% vs 10.5%, P = 0.001), gingival bleeding/hemoptysis (18.5% vs 4.8%, P = 0.015) and rash (33.3% vs 4.8%, P < 0.001) in the anlotinib group than in the observation group. Conclusion Maintenance therapy with anlotinib improved the survival of patients with ES-SCLC after first-line chemotherapy and CTRT. Owing to the small sample size of the real-world trial, the reliability of our study needs to be confirmed in more studies.https://doi.org/10.1177/15330338251317571 |
| spellingShingle | Jinbo Ma MD Xiaoyan Ma MS Wei Zhang MD Shanliang Hu MS Rukun Zang MS Xiaolong Wu MS Jie Song MD Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer Technology in Cancer Research & Treatment |
| title | Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer |
| title_full | Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer |
| title_fullStr | Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer |
| title_full_unstemmed | Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer |
| title_short | Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer |
| title_sort | anlotinib as maintenance therapy after first line chemotherapy combined with consolidation radiation for extensive stage small cell lung cancer |
| url | https://doi.org/10.1177/15330338251317571 |
| work_keys_str_mv | AT jinbomamd anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer AT xiaoyanmams anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer AT weizhangmd anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer AT shanlianghums anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer AT rukunzangms anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer AT xiaolongwums anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer AT jiesongmd anlotinibasmaintenancetherapyafterfirstlinechemotherapycombinedwithconsolidationradiationforextensivestagesmallcelllungcancer |