PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia
Promyelocytic blast crisis arising from chronic myeloid leukemia (CML) is rare. We present a 40-year-old male who developed promyelocytic blast crisis 17 months after CML diagnosis, confirmed by the presence of the t(15;17) and t(9;22) translocations in the leukemic cells. Preserved nucleic acids fr...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8830595 |
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| author | Stephanie Wolanin Robert K. McCall Mark J. Pettenati Michael W. Beaty Giovanni Insuasti-Beltran Bayard L. Powell Stacey S. O’Neill |
| author_facet | Stephanie Wolanin Robert K. McCall Mark J. Pettenati Michael W. Beaty Giovanni Insuasti-Beltran Bayard L. Powell Stacey S. O’Neill |
| author_sort | Stephanie Wolanin |
| collection | DOAJ |
| description | Promyelocytic blast crisis arising from chronic myeloid leukemia (CML) is rare. We present a 40-year-old male who developed promyelocytic blast crisis 17 months after CML diagnosis, confirmed by the presence of the t(15;17) and t(9;22) translocations in the leukemic cells. Preserved nucleic acids from routine BCR-ABL1 testing provided a unique opportunity to evaluate clonal progression over time. Retrospective analysis demonstrated PML-RARA fusion transcripts were first detectable 8 months prior to blast crisis presentation. A review of 21 cases of promyelocytic blasts crisis published in the literature reveals a male predominance with earlier age at onset as compared to females. Interestingly, TKI therapy during chronic phase did not impact the time interval between diagnosis and promyelocytic blast crisis. Treatment with standard acute promyelocytic leukemia regimens provides more favorable outcomes with complete molecular remission. Although rare, it is important to consider a promyelocytic blast crisis when evaluating for transformation of CML due to its effective treatment with specific therapies. |
| format | Article |
| id | doaj-art-ac6b125e32014a94aac2c3874ce1f702 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-ac6b125e32014a94aac2c3874ce1f7022025-02-03T05:53:54ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/88305958830595PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid LeukemiaStephanie Wolanin0Robert K. McCall1Mark J. Pettenati2Michael W. Beaty3Giovanni Insuasti-Beltran4Bayard L. Powell5Stacey S. O’Neill6Wake Forest Baptist Medical Center, Department of Pathology, Winston-Salem, NC, USAMolecular Pathology Laboratory Network, Maryville, TN, USAWake Forest Baptist Medical Center, Department of Pathology, Winston-Salem, NC, USAWake Forest Baptist Medical Center, Department of Pathology, Winston-Salem, NC, USAWake Forest Baptist Medical Center, Department of Pathology, Winston-Salem, NC, USAWake Forest Baptist Comprehensive Cancer Center, Section on Hematology and Oncology, Winston-Salem, NC, USAWake Forest Baptist Medical Center, Department of Pathology, Winston-Salem, NC, USAPromyelocytic blast crisis arising from chronic myeloid leukemia (CML) is rare. We present a 40-year-old male who developed promyelocytic blast crisis 17 months after CML diagnosis, confirmed by the presence of the t(15;17) and t(9;22) translocations in the leukemic cells. Preserved nucleic acids from routine BCR-ABL1 testing provided a unique opportunity to evaluate clonal progression over time. Retrospective analysis demonstrated PML-RARA fusion transcripts were first detectable 8 months prior to blast crisis presentation. A review of 21 cases of promyelocytic blasts crisis published in the literature reveals a male predominance with earlier age at onset as compared to females. Interestingly, TKI therapy during chronic phase did not impact the time interval between diagnosis and promyelocytic blast crisis. Treatment with standard acute promyelocytic leukemia regimens provides more favorable outcomes with complete molecular remission. Although rare, it is important to consider a promyelocytic blast crisis when evaluating for transformation of CML due to its effective treatment with specific therapies.http://dx.doi.org/10.1155/2020/8830595 |
| spellingShingle | Stephanie Wolanin Robert K. McCall Mark J. Pettenati Michael W. Beaty Giovanni Insuasti-Beltran Bayard L. Powell Stacey S. O’Neill PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia Case Reports in Hematology |
| title | PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia |
| title_full | PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia |
| title_fullStr | PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia |
| title_full_unstemmed | PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia |
| title_short | PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia |
| title_sort | pml rara fusion transcripts detectable 8 months prior to promyelocytic blast crisis in chronic myeloid leukemia |
| url | http://dx.doi.org/10.1155/2020/8830595 |
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