Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia?
Leukemia is a hematologic malignancy; acute lymphoblastic leukemia (ALL) is the most prevalent subtype among children rather than in adults. <i>Orthoherpesviridae</i> family members produce proteins during latent infection phases that may contribute to cancer development. One such protei...
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2025-03-01
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| author | Ruvalcaba-Hernández Pamela Mata-Rocha Minerva Cruz-Muñoz Mario Ernesto Mejía-Aranguré Juan Manuel Sánchez-Escobar Norberto Arenas-Huertero Francisco Melchor-Doncel de la Torre Silvia Rangel-López Angélica Jiménez-Hernández Elva Nuñez-Enriquez Juan Carlos Ochoa Sara Xicohtencatl-Cortes Juan Cruz-Córdova Ariadnna Figueroa-Arredondo Paula Arellano-Galindo José |
| author_facet | Ruvalcaba-Hernández Pamela Mata-Rocha Minerva Cruz-Muñoz Mario Ernesto Mejía-Aranguré Juan Manuel Sánchez-Escobar Norberto Arenas-Huertero Francisco Melchor-Doncel de la Torre Silvia Rangel-López Angélica Jiménez-Hernández Elva Nuñez-Enriquez Juan Carlos Ochoa Sara Xicohtencatl-Cortes Juan Cruz-Córdova Ariadnna Figueroa-Arredondo Paula Arellano-Galindo José |
| author_sort | Ruvalcaba-Hernández Pamela |
| collection | DOAJ |
| description | Leukemia is a hematologic malignancy; acute lymphoblastic leukemia (ALL) is the most prevalent subtype among children rather than in adults. <i>Orthoherpesviridae</i> family members produce proteins during latent infection phases that may contribute to cancer development. One such protein, viral interleukin-10 (vIL-10), closely resembles human interleukin-10 (IL-10) in structure. Research has explored the involvement of human cytomegalovirus (hCMV) in the pathogenesis of ALL. However, the limited characterization of its latent-phase proteins restricts a full understanding of the relationship between hCMV infection and leukemia progression. Studies have shown that hCMV induces an inflammatory response during infection, marked by the release of cytokines and chemokines. Inflammation may, therefore, play a role in how hCMV contributes to oncogenesis in pediatric ALL, possibly mediated by latent viral proteins. The classification of a virus as oncogenic is based on its alignment with cancer’s established hallmarks. Viruses can manipulate host cellular mechanisms, causing dysregulated cell proliferation, evasion of apoptosis, and genomic instability. These processes lead to mutations, chromosomal abnormalities, and chronic inflammation, all of which are vital for carcinogenesis. This study aims to investigate the role of vIL-10 during the latent phase of hCMV as a potential factor in leukemia development. |
| format | Article |
| id | doaj-art-ac64a1e5d55a4d9aaf6e8e1eb7dc4a6c |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Viruses |
| spelling | doaj-art-ac64a1e5d55a4d9aaf6e8e1eb7dc4a6c2025-08-20T01:50:10ZengMDPI AGViruses1999-49152025-03-0117343510.3390/v17030435Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia?Ruvalcaba-Hernández Pamela0Mata-Rocha Minerva1Cruz-Muñoz Mario Ernesto2Mejía-Aranguré Juan Manuel3Sánchez-Escobar Norberto4Arenas-Huertero Francisco5Melchor-Doncel de la Torre Silvia6Rangel-López Angélica7Jiménez-Hernández Elva8Nuñez-Enriquez Juan Carlos9Ochoa Sara10Xicohtencatl-Cortes Juan11Cruz-Córdova Ariadnna12Figueroa-Arredondo Paula13Arellano-Galindo José14Laboratorio de Virología, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoUnidad de Investigación en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc 330, Doctores, Ciudad de México 06720, MexicoFacultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, MexicoUnidad de Investigación en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc 330, Doctores, Ciudad de México 06720, MexicoLaboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, MexicoLaboratorio de Virología, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoLaboratorio de Virología, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoDepartamento de Oncología, Hospital Pediátrico Moctezuma SEDESA, Universidad Autónoma Metropolitana, Mexico City 09769, MexicoUnidad de Investigación Médica en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoLaboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoLaboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoLaboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoEscuela Superior de Medicina del Instituto Politécnico Nacional, Mexico City 11340, MexicoLaboratorio de Virología, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoLeukemia is a hematologic malignancy; acute lymphoblastic leukemia (ALL) is the most prevalent subtype among children rather than in adults. <i>Orthoherpesviridae</i> family members produce proteins during latent infection phases that may contribute to cancer development. One such protein, viral interleukin-10 (vIL-10), closely resembles human interleukin-10 (IL-10) in structure. Research has explored the involvement of human cytomegalovirus (hCMV) in the pathogenesis of ALL. However, the limited characterization of its latent-phase proteins restricts a full understanding of the relationship between hCMV infection and leukemia progression. Studies have shown that hCMV induces an inflammatory response during infection, marked by the release of cytokines and chemokines. Inflammation may, therefore, play a role in how hCMV contributes to oncogenesis in pediatric ALL, possibly mediated by latent viral proteins. The classification of a virus as oncogenic is based on its alignment with cancer’s established hallmarks. Viruses can manipulate host cellular mechanisms, causing dysregulated cell proliferation, evasion of apoptosis, and genomic instability. These processes lead to mutations, chromosomal abnormalities, and chronic inflammation, all of which are vital for carcinogenesis. This study aims to investigate the role of vIL-10 during the latent phase of hCMV as a potential factor in leukemia development.https://www.mdpi.com/1999-4915/17/3/435vIL10ALL (Acute lymphoblastic leukemia)hCMV (Cytomegalovirus)latent proteins |
| spellingShingle | Ruvalcaba-Hernández Pamela Mata-Rocha Minerva Cruz-Muñoz Mario Ernesto Mejía-Aranguré Juan Manuel Sánchez-Escobar Norberto Arenas-Huertero Francisco Melchor-Doncel de la Torre Silvia Rangel-López Angélica Jiménez-Hernández Elva Nuñez-Enriquez Juan Carlos Ochoa Sara Xicohtencatl-Cortes Juan Cruz-Córdova Ariadnna Figueroa-Arredondo Paula Arellano-Galindo José Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia? Viruses vIL10 ALL (Acute lymphoblastic leukemia) hCMV (Cytomegalovirus) latent proteins |
| title | Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia? |
| title_full | Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia? |
| title_fullStr | Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia? |
| title_full_unstemmed | Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia? |
| title_short | Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia? |
| title_sort | is the vil 10 protein from cytomegalovirus associated with the potential development of acute lymphoblastic leukemia |
| topic | vIL10 ALL (Acute lymphoblastic leukemia) hCMV (Cytomegalovirus) latent proteins |
| url | https://www.mdpi.com/1999-4915/17/3/435 |
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