Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China
Avian hepatitis E virus (HEV) is recognized as the primary causative agent of big liver and spleen disease, hepatitis-splenomegaly syndrome, and hepatic rupture hemorrhage syndrome, resulting in substantial economic losses within the global poultry industry. Since its discovery in 1991, diverse stra...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124011350 |
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| author | Xue-Lian Zhang Yu-Qian Zhang Chun-Hong Liu Yan Ma Shu-Jian Huang Jian-Wei Shao |
| author_facet | Xue-Lian Zhang Yu-Qian Zhang Chun-Hong Liu Yan Ma Shu-Jian Huang Jian-Wei Shao |
| author_sort | Xue-Lian Zhang |
| collection | DOAJ |
| description | Avian hepatitis E virus (HEV) is recognized as the primary causative agent of big liver and spleen disease, hepatitis-splenomegaly syndrome, and hepatic rupture hemorrhage syndrome, resulting in substantial economic losses within the global poultry industry. Since its discovery in 1991, diverse strains of avian HEV have been extensively identified worldwide. Epidemiological investigations have demonstrated the wide distribution and genetic diversity of avian HEV strains in China. In this study, avian HEV strains were identified in chickens exhibiting hepatitis-splenomegaly syndrome in Guangdong province, China. Sequence analysis indicated that these strains shared the highest nucleotide sequence identities with genotype 3 strains, and phylogenetic analysis demonstrated that they clustered with strains belonging to avian HEV genotype 3. Moreover, a statistically supported recombination event was detected within one of the avian HEV strain identified in this study. These findings significantly enhance our understanding of the genetic diversity and evolution of avian HEV in chickens, providing new insights for disease prevention and control strategies. |
| format | Article |
| id | doaj-art-ac5bb44de8f14ada8172ccd18ec6e593 |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-ac5bb44de8f14ada8172ccd18ec6e5932025-01-22T05:40:28ZengElsevierPoultry Science0032-57912025-01-011041104557Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, ChinaXue-Lian Zhang0Yu-Qian Zhang1Chun-Hong Liu2Yan Ma3Shu-Jian Huang4Jian-Wei Shao5School of Animal Science and Technology, Foshan University, Foshan, Guangdong Province, ChinaSchool of Animal Science and Technology, Foshan University, Foshan, Guangdong Province, ChinaSchool of Animal Science and Technology, Foshan University, Foshan, Guangdong Province, ChinaAnimal Disease Prevention and Control Center of Guoluo Prefecture, Qinghai Province, ChinaSchool of Animal Science and Technology, Foshan University, Foshan, Guangdong Province, ChinaSchool of Animal Science and Technology, Foshan University, Foshan, Guangdong Province, China; Corresponding author.Avian hepatitis E virus (HEV) is recognized as the primary causative agent of big liver and spleen disease, hepatitis-splenomegaly syndrome, and hepatic rupture hemorrhage syndrome, resulting in substantial economic losses within the global poultry industry. Since its discovery in 1991, diverse strains of avian HEV have been extensively identified worldwide. Epidemiological investigations have demonstrated the wide distribution and genetic diversity of avian HEV strains in China. In this study, avian HEV strains were identified in chickens exhibiting hepatitis-splenomegaly syndrome in Guangdong province, China. Sequence analysis indicated that these strains shared the highest nucleotide sequence identities with genotype 3 strains, and phylogenetic analysis demonstrated that they clustered with strains belonging to avian HEV genotype 3. Moreover, a statistically supported recombination event was detected within one of the avian HEV strain identified in this study. These findings significantly enhance our understanding of the genetic diversity and evolution of avian HEV in chickens, providing new insights for disease prevention and control strategies.http://www.sciencedirect.com/science/article/pii/S0032579124011350Avian hepatitis E virusGenetic diversityNovel subtypeRecombinationHepatitis-splenomegaly syndrome |
| spellingShingle | Xue-Lian Zhang Yu-Qian Zhang Chun-Hong Liu Yan Ma Shu-Jian Huang Jian-Wei Shao Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China Poultry Science Avian hepatitis E virus Genetic diversity Novel subtype Recombination Hepatitis-splenomegaly syndrome |
| title | Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China |
| title_full | Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China |
| title_fullStr | Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China |
| title_full_unstemmed | Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China |
| title_short | Research note: Genetically diverse avian hepatitis E virus identified in chickens with hepatitis-splenomegaly syndrome in Guangdong Province, China |
| title_sort | research note genetically diverse avian hepatitis e virus identified in chickens with hepatitis splenomegaly syndrome in guangdong province china |
| topic | Avian hepatitis E virus Genetic diversity Novel subtype Recombination Hepatitis-splenomegaly syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124011350 |
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