Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii
Struma ovarii is an uncommon type of ovarian mature teratoma with a predominant thyroid component. The morphological spectrum of the thyroid tissue ranges from that of normal thyroid to proliferative adenoma-like lesions and thyroid-type carcinomas (malignant transformation). The histologic features...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/826978 |
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| author | Surapan Khunamornpong Jongkolnee Settakorn Kornkanok Sukpan Prapaporn Suprasert Sumalee Siriaunkgul |
| author_facet | Surapan Khunamornpong Jongkolnee Settakorn Kornkanok Sukpan Prapaporn Suprasert Sumalee Siriaunkgul |
| author_sort | Surapan Khunamornpong |
| collection | DOAJ |
| description | Struma ovarii is an uncommon type of ovarian mature teratoma with a predominant thyroid component. The morphological spectrum of the thyroid tissue ranges from that of normal thyroid to proliferative adenoma-like lesions and thyroid-type carcinomas (malignant transformation). The histologic features of ovarian strumal lesions sometimes cause diagnostic problems due to the confusion with other types of ovarian neoplasms and the difficulty in the prediction of their clinical behavior. We report an extremely rare case of poorly differentiated thyroid carcinoma arising in struma ovarii. A 22-year-old woman presented with a 15 cm right ovarian mass. The tumor showed a predominantly tubular pattern which raised a differential diagnosis between endometrioid adenocarcinoma and Sertoli cell tumor. A review of the gross specimen with additional tissue sampling helped identify the teratomatous and strumal nature, with a support by immunohistochemical staining. Despite FIGO stage IA by optimal staging procedure and the absence of identifiable lymphovascular invasion, the patient developed pulmonary metastasis 15 months after surgery and died from the progression of the disease 7 years after the diagnosis. This case emphasizes the importance of macroscopic examination of the specimen and the awareness of this uncommon tumor in the differential diagnosis of ovarian neoplasms. |
| format | Article |
| id | doaj-art-ac3e22d18d584f13ac0a4573b3fbabb1 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-ac3e22d18d584f13ac0a4573b3fbabb12025-02-03T01:01:09ZengWileyCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/826978826978Poorly Differentiated Thyroid Carcinoma Arising in Struma OvariiSurapan Khunamornpong0Jongkolnee Settakorn1Kornkanok Sukpan2Prapaporn Suprasert3Sumalee Siriaunkgul4Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandStruma ovarii is an uncommon type of ovarian mature teratoma with a predominant thyroid component. The morphological spectrum of the thyroid tissue ranges from that of normal thyroid to proliferative adenoma-like lesions and thyroid-type carcinomas (malignant transformation). The histologic features of ovarian strumal lesions sometimes cause diagnostic problems due to the confusion with other types of ovarian neoplasms and the difficulty in the prediction of their clinical behavior. We report an extremely rare case of poorly differentiated thyroid carcinoma arising in struma ovarii. A 22-year-old woman presented with a 15 cm right ovarian mass. The tumor showed a predominantly tubular pattern which raised a differential diagnosis between endometrioid adenocarcinoma and Sertoli cell tumor. A review of the gross specimen with additional tissue sampling helped identify the teratomatous and strumal nature, with a support by immunohistochemical staining. Despite FIGO stage IA by optimal staging procedure and the absence of identifiable lymphovascular invasion, the patient developed pulmonary metastasis 15 months after surgery and died from the progression of the disease 7 years after the diagnosis. This case emphasizes the importance of macroscopic examination of the specimen and the awareness of this uncommon tumor in the differential diagnosis of ovarian neoplasms.http://dx.doi.org/10.1155/2015/826978 |
| spellingShingle | Surapan Khunamornpong Jongkolnee Settakorn Kornkanok Sukpan Prapaporn Suprasert Sumalee Siriaunkgul Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii Case Reports in Pathology |
| title | Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii |
| title_full | Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii |
| title_fullStr | Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii |
| title_full_unstemmed | Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii |
| title_short | Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii |
| title_sort | poorly differentiated thyroid carcinoma arising in struma ovarii |
| url | http://dx.doi.org/10.1155/2015/826978 |
| work_keys_str_mv | AT surapankhunamornpong poorlydifferentiatedthyroidcarcinomaarisinginstrumaovarii AT jongkolneesettakorn poorlydifferentiatedthyroidcarcinomaarisinginstrumaovarii AT kornkanoksukpan poorlydifferentiatedthyroidcarcinomaarisinginstrumaovarii AT prapapornsuprasert poorlydifferentiatedthyroidcarcinomaarisinginstrumaovarii AT sumaleesiriaunkgul poorlydifferentiatedthyroidcarcinomaarisinginstrumaovarii |