Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development
The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/637208 |
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| _version_ | 1832547102376329216 |
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| author | Gamze Isitman Ivan Stratov Stephen J. Kent |
| author_facet | Gamze Isitman Ivan Stratov Stephen J. Kent |
| author_sort | Gamze Isitman |
| collection | DOAJ |
| description | The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune escape through both direct Killer-immunoglobulin-like receptor (KIR)-mediated killing as well as through facilitating antibody-dependent cellular cytotoxicity (ADCC). These newer finding suggest NK cells and ADCC responses apply significant pressure to the virus. There is an opportunity to harness these immune responses in the design of more effective HIV vaccines. |
| format | Article |
| id | doaj-art-ac3be96b0bd4413a974f91c068cd29f6 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-ac3be96b0bd4413a974f91c068cd29f62025-02-03T06:46:13ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/637208637208Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine DevelopmentGamze Isitman0Ivan Stratov1Stephen J. Kent2Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Microbiology and Immunology, University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Microbiology and Immunology, University of Melbourne, Melbourne, VIC 3010, AustraliaThe HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune escape through both direct Killer-immunoglobulin-like receptor (KIR)-mediated killing as well as through facilitating antibody-dependent cellular cytotoxicity (ADCC). These newer finding suggest NK cells and ADCC responses apply significant pressure to the virus. There is an opportunity to harness these immune responses in the design of more effective HIV vaccines.http://dx.doi.org/10.1155/2012/637208 |
| spellingShingle | Gamze Isitman Ivan Stratov Stephen J. Kent Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development Advances in Virology |
| title | Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development |
| title_full | Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development |
| title_fullStr | Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development |
| title_full_unstemmed | Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development |
| title_short | Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development |
| title_sort | antibody dependent cellular cytotoxicity and nk cell driven immune escape in hiv infection implications for hiv vaccine development |
| url | http://dx.doi.org/10.1155/2012/637208 |
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