Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus

Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus

Every year, dengue virus affects hundreds of millions of individuals worldwide. To date, there is no specific medication to treat dengue virus infections. Nucleobases, the base of a nucleoside without ribose, are understudied as potential treatments for viral infections. Antiviral nucleobases are co...

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Bibliographic Details
Main Authors: Laurent F. Bonnac, Christine D. Dreis, Madhu Rai, Robert J. Geraghty
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
broad-spectrum antivirals
nucleobases
drug combination
flaviviruses
Online Access:https://www.mdpi.com/1420-3049/30/2/210
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