Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol
Introduction Patients with inflammatory bowel diseases (IBD) often report psychological problems, unemployment, disability, sick leave and compromised quality of life. The effect of psychological interventions on health-related outcomes in IBD is controversial as previous reviews faced the obstacle...
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| Format: | Article |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e056982.full |
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| author | Antje Timmer Gerta Rücker Natalia Tiles-Sar Johanna Neuser Dominik de Sordi Anne Baltes Jan Preiss Gabriele Moser |
| author_facet | Antje Timmer Gerta Rücker Natalia Tiles-Sar Johanna Neuser Dominik de Sordi Anne Baltes Jan Preiss Gabriele Moser |
| author_sort | Antje Timmer |
| collection | DOAJ |
| description | Introduction Patients with inflammatory bowel diseases (IBD) often report psychological problems, unemployment, disability, sick leave and compromised quality of life. The effect of psychological interventions on health-related outcomes in IBD is controversial as previous reviews faced the obstacle of high heterogeneity among provided multimodular interventions. The heterogeneity can be addressed with network meta-analysis (NMA) and (multi)component NMA (CNMA). We aim to investigate whether psychological interventions can improve quality of life, clinical and social outcomes in IBD using NMA and CNMA. This is the study protocol.Methods and analysis We will consider randomised, quasi-randomised and non-randomised controlled trials, including cluster randomised and cross-over trials with 2 months of minimum follow-up. The conditions to be studied comprise Crohn’s disease and ulcerative colitis in children, adolescents and adults. We will include any psychological intervention aiming to change the health status of the study participant.We will search Medline, Embase, Web of Science, CENTRAL, LILACS, Psyndex, PsycINFO, Google Scholar and trial registries from inception (the search will be updated before the review completion). Two authors will independently screen all references based on titles and abstracts. For data extraction, standard forms are developed and tested before extraction. All information will be assessed independently by at least two reviewers, and disagreements solved by consensus discussion or a third rater if necessary.The data synthesis will include a pairwise meta-analysis supported by meta-regression. We will conduct NMA (all treatments will constitute single nodes of the network) and CNMA (we will define all treatments as sums of core components, eg, cognitive +behaviour, or cognitive +behaviour + relaxation, and additionally consider interactions) using the R Package netmeta.Ethics and dissemination No ethical approval is required. Reports will include the final report to the funder, conference presentation, peer-reviewed publication and a patient report.PROSPERO registration number CRD42021250446. |
| format | Article |
| id | doaj-art-ac1b8f2a936345868d9f039f09ebbff6 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-ac1b8f2a936345868d9f039f09ebbff62025-01-28T07:30:13ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-056982Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocolAntje Timmer0Gerta Rücker1Natalia Tiles-Sar2Johanna Neuser3Dominik de Sordi4Anne Baltes5Jan Preiss6Gabriele Moser7Department of Epidemiology and Biometry, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center – University of Freiburg, Freiburg im Breisgau, GermanyDepartment of Epidemiology and Biometry, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyDepartment of Epidemiology and Biometry, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyDepartment of Epidemiology and Biometry, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyGerman Association for Crohn’s Disease and Ulcerative Colitis (DCCV e.V.), Berlin, GermanyClinic for Internal Medicine - Gastroenterology, Diabetology and Hepatology, Vivantes Klinikum Neukölln, Berlin, GermanyDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, AustriaIntroduction Patients with inflammatory bowel diseases (IBD) often report psychological problems, unemployment, disability, sick leave and compromised quality of life. The effect of psychological interventions on health-related outcomes in IBD is controversial as previous reviews faced the obstacle of high heterogeneity among provided multimodular interventions. The heterogeneity can be addressed with network meta-analysis (NMA) and (multi)component NMA (CNMA). We aim to investigate whether psychological interventions can improve quality of life, clinical and social outcomes in IBD using NMA and CNMA. This is the study protocol.Methods and analysis We will consider randomised, quasi-randomised and non-randomised controlled trials, including cluster randomised and cross-over trials with 2 months of minimum follow-up. The conditions to be studied comprise Crohn’s disease and ulcerative colitis in children, adolescents and adults. We will include any psychological intervention aiming to change the health status of the study participant.We will search Medline, Embase, Web of Science, CENTRAL, LILACS, Psyndex, PsycINFO, Google Scholar and trial registries from inception (the search will be updated before the review completion). Two authors will independently screen all references based on titles and abstracts. For data extraction, standard forms are developed and tested before extraction. All information will be assessed independently by at least two reviewers, and disagreements solved by consensus discussion or a third rater if necessary.The data synthesis will include a pairwise meta-analysis supported by meta-regression. We will conduct NMA (all treatments will constitute single nodes of the network) and CNMA (we will define all treatments as sums of core components, eg, cognitive +behaviour, or cognitive +behaviour + relaxation, and additionally consider interactions) using the R Package netmeta.Ethics and dissemination No ethical approval is required. Reports will include the final report to the funder, conference presentation, peer-reviewed publication and a patient report.PROSPERO registration number CRD42021250446.https://bmjopen.bmj.com/content/12/6/e056982.full |
| spellingShingle | Antje Timmer Gerta Rücker Natalia Tiles-Sar Johanna Neuser Dominik de Sordi Anne Baltes Jan Preiss Gabriele Moser Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol BMJ Open |
| title | Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol |
| title_full | Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol |
| title_fullStr | Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol |
| title_full_unstemmed | Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol |
| title_short | Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol |
| title_sort | psychological interventions for inflammatory bowel disease a systematic review and component network meta analysis protocol |
| url | https://bmjopen.bmj.com/content/12/6/e056982.full |
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