Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells

Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells

Abstract As a novel form of nonapoptotic cell death, ferroptosis is developing into a promising therapeutic target of dedifferentiating and therapy-refractory cancers. However, its application in pancreatic cancer is still unknown. In the preliminary research, we found that F-box and WD repeat domai...

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Main Authors: Zheng Zhang, Huaxiang Xu, Junyi He, Qiangsheng Hu, Yuxin Liu, Zijin Xu, Wenhui Lou, Wenchuan Wu, Lei Zhang, Ning Pu, Chenye Shi, Yaolin Xu, Wenquan Wang, Liang Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07330-8
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