Markers of immunosenescence in CMV seropositive healthy elderly adults
A significant increase in life expectancy has accompanied the growth of the world’s population. Approximately 10% of the global population are adults over 60, and it is estimated that 2050 this figure will double. This increase in the proportion of older adults leads to a more significant burden of...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2024.1436346/full |
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| author | Ivón Johanna Rodríguez Carlos Alberto Parra-López |
| author_facet | Ivón Johanna Rodríguez Carlos Alberto Parra-López |
| author_sort | Ivón Johanna Rodríguez |
| collection | DOAJ |
| description | A significant increase in life expectancy has accompanied the growth of the world’s population. Approximately 10% of the global population are adults over 60, and it is estimated that 2050 this figure will double. This increase in the proportion of older adults leads to a more significant burden of age-related diseases. Immunosenescence predisposes elderly individuals to a higher incidence of infectious and chronic non-communicable diseases with higher mortality rates. Despite advances in research, it is necessary to evaluate the cellular characteristics of the aging immune system in populations with a high incidence of latent viruses such as cytomegalovirus (CMV). In this sense, this work aimed to identify senescence markers in cells of the innate and adaptive immune system in healthy older adults with CMV infection. We observed that older adults present an increase in the population of CD14+CD16+ intermediate monocytes, an expansion of CD56neg NK cells with an increase in the expression of CD57, as well as a decrease in the naïve CD4+ and CD8+ T cells, accompanied by an increased expression of senescence markers CD57 and KLRG1 in effector CD8+ T cells. |
| format | Article |
| id | doaj-art-ac0dd5c8c4674ada9d1615c7a74ea05a |
| institution | Kabale University |
| issn | 2673-6217 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj-art-ac0dd5c8c4674ada9d1615c7a74ea05a2025-01-23T06:56:11ZengFrontiers Media S.A.Frontiers in Aging2673-62172025-01-01510.3389/fragi.2024.14363461436346Markers of immunosenescence in CMV seropositive healthy elderly adultsIvón Johanna Rodríguez0Carlos Alberto Parra-López1Grupo de profundización en Kinesioterapia, Departamento de Movimiento Corporal Humano, Universidad Nacional de Colombia, Bogotá, ColombiaGrupo de Inmunología y Medicina Traslacional, Departamento de Microbiología, Universidad Nacional de Colombia, Bogotá, ColombiaA significant increase in life expectancy has accompanied the growth of the world’s population. Approximately 10% of the global population are adults over 60, and it is estimated that 2050 this figure will double. This increase in the proportion of older adults leads to a more significant burden of age-related diseases. Immunosenescence predisposes elderly individuals to a higher incidence of infectious and chronic non-communicable diseases with higher mortality rates. Despite advances in research, it is necessary to evaluate the cellular characteristics of the aging immune system in populations with a high incidence of latent viruses such as cytomegalovirus (CMV). In this sense, this work aimed to identify senescence markers in cells of the innate and adaptive immune system in healthy older adults with CMV infection. We observed that older adults present an increase in the population of CD14+CD16+ intermediate monocytes, an expansion of CD56neg NK cells with an increase in the expression of CD57, as well as a decrease in the naïve CD4+ and CD8+ T cells, accompanied by an increased expression of senescence markers CD57 and KLRG1 in effector CD8+ T cells.https://www.frontiersin.org/articles/10.3389/fragi.2024.1436346/fullimmunosenescenceT cellsNK cellsmonocytesflow cytometry |
| spellingShingle | Ivón Johanna Rodríguez Carlos Alberto Parra-López Markers of immunosenescence in CMV seropositive healthy elderly adults Frontiers in Aging immunosenescence T cells NK cells monocytes flow cytometry |
| title | Markers of immunosenescence in CMV seropositive healthy elderly adults |
| title_full | Markers of immunosenescence in CMV seropositive healthy elderly adults |
| title_fullStr | Markers of immunosenescence in CMV seropositive healthy elderly adults |
| title_full_unstemmed | Markers of immunosenescence in CMV seropositive healthy elderly adults |
| title_short | Markers of immunosenescence in CMV seropositive healthy elderly adults |
| title_sort | markers of immunosenescence in cmv seropositive healthy elderly adults |
| topic | immunosenescence T cells NK cells monocytes flow cytometry |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2024.1436346/full |
| work_keys_str_mv | AT ivonjohannarodriguez markersofimmunosenescenceincmvseropositivehealthyelderlyadults AT carlosalbertoparralopez markersofimmunosenescenceincmvseropositivehealthyelderlyadults |