Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome
Perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) are emerging environmental contaminants with recognized potential health and ecological risks. This study investigated the effects of PFOA and TBBP-A exposure on the global of metabolites of silkworm gut with GC-MS metabolomics. Our re...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015203 |
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| author | Xing Zhang Yifei Kong Zihan He Wenbin Yu Wenjing Shao Chengliang Gong Wenlin Zhou Xiaolong Hu |
| author_facet | Xing Zhang Yifei Kong Zihan He Wenbin Yu Wenjing Shao Chengliang Gong Wenlin Zhou Xiaolong Hu |
| author_sort | Xing Zhang |
| collection | DOAJ |
| description | Perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) are emerging environmental contaminants with recognized potential health and ecological risks. This study investigated the effects of PFOA and TBBP-A exposure on the global of metabolites of silkworm gut with GC-MS metabolomics. Our results revealed distinct metabolic alterations in silkworms exposed to PFOA and TBBP-A, highlighting their differential impacts on silkworm health and productivity. Exposure to these chemicals significantly altered metabolic profiles, leading to disruptions in pathways related to lipid, carbohydrate, and amino acid metabolism. These findings suggest that PFOA and TBBP-A disrupt crucial metabolic processes in silkworms, indicating potential toxicity and prompting further investigation into their effects on human health and the environment. Ongoing research is crucial to develop safer alternatives and mitigate the risks associated with these persistent contaminants. |
| format | Article |
| id | doaj-art-abfb228482ac4022bd6b3ff8d0537d10 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-abfb228482ac4022bd6b3ff8d0537d102025-01-23T05:25:33ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117444Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolomeXing Zhang0Yifei Kong1Zihan He2Wenbin Yu3Wenjing Shao4Chengliang Gong5Wenlin Zhou6Xiaolong Hu7School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, ChinaSchool of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, ChinaInstitute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaSchool of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China; Corresponding author.Perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) are emerging environmental contaminants with recognized potential health and ecological risks. This study investigated the effects of PFOA and TBBP-A exposure on the global of metabolites of silkworm gut with GC-MS metabolomics. Our results revealed distinct metabolic alterations in silkworms exposed to PFOA and TBBP-A, highlighting their differential impacts on silkworm health and productivity. Exposure to these chemicals significantly altered metabolic profiles, leading to disruptions in pathways related to lipid, carbohydrate, and amino acid metabolism. These findings suggest that PFOA and TBBP-A disrupt crucial metabolic processes in silkworms, indicating potential toxicity and prompting further investigation into their effects on human health and the environment. Ongoing research is crucial to develop safer alternatives and mitigate the risks associated with these persistent contaminants.http://www.sciencedirect.com/science/article/pii/S0147651324015203PFOATBBPASilkwormMetaboliteExposure |
| spellingShingle | Xing Zhang Yifei Kong Zihan He Wenbin Yu Wenjing Shao Chengliang Gong Wenlin Zhou Xiaolong Hu Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome Ecotoxicology and Environmental Safety PFOA TBBPA Silkworm Metabolite Exposure |
| title | Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome |
| title_full | Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome |
| title_fullStr | Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome |
| title_full_unstemmed | Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome |
| title_short | Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome |
| title_sort | exploring the effects of perfluorooctanoic acid pfoa and tetrabromobisphenol a tbbp a on silkworm from the insights of metabolome |
| topic | PFOA TBBPA Silkworm Metabolite Exposure |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015203 |
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