MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics

MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics

Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase featured by a protein kinase-like domain without catalytic activity. MLKL was originally discovered to be phosphorylated by receptor-interacting protein kinase 1/3, typically increase plasma membrane permeabilization, and disrupt the...

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Bibliographic Details
Main Authors: Yang Wang, Wei Wei, Yu Zhang, Jingrong Miao, Xiaofeng Bao, Chunfeng Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
MLKL
organelle dynamics
disease target
small-molecule chemicals
natural products
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1512968/full
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