(+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats
We have previously reported that the synthetic estrogen, (+)-Z-bisdehydrodoisynolic Acid [(+)-Z-BDDA], attenuated weight gain and cardiovascular risk in obese rodents. To determine if these antiobesity effects were attributed to changes in basal metabolism, we assessed indirect calorimetry and metab...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/154145 |
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| author | William J. Banz April D. Strader Kolapo M. Ajuwon Yuqing Hou Cal Y. Meyers Jeremy E. Davis |
| author_facet | William J. Banz April D. Strader Kolapo M. Ajuwon Yuqing Hou Cal Y. Meyers Jeremy E. Davis |
| author_sort | William J. Banz |
| collection | DOAJ |
| description | We have previously reported that the synthetic estrogen, (+)-Z-bisdehydrodoisynolic Acid [(+)-Z-BDDA], attenuated weight gain and cardiovascular risk in obese rodents. To determine if these antiobesity effects were attributed to changes in basal metabolism, we assessed indirect calorimetry and metabolic profile in female obese Zucker (OZR) rats provided (+)-Z-BDDA (0.0002% food admixture) for 11 weeks. Similar to our previous findings, (+)-Z-BDDA reduced weight gain and improved lipid and glucose homeostasis in OZR rats. Furthermore, resting energy expenditure was increased by (+)-Z-BDDA, as evident by heat production and oxygen consumption. We also observed a marked reduction in respiratory quotient (RQ) along with a corresponding induction of hepatic AMPK in rodents provided (+)-Z-BDDA. Collectively, these findings indicate that (+)-Z-BDDA partially attenuated obesity and associated pathologies through increased resting energy expenditure and fatty acid utilization. Further investigation is required to fully elucidate the mechanisms involved as well as to determine the potential therapeutic implications for (+)-Z-BDDA on obesity and its related pathologies. |
| format | Article |
| id | doaj-art-abe2fb42c48a4328b8519cf3624f5486 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-abe2fb42c48a4328b8519cf3624f54862025-02-03T05:53:36ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/154145154145(+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker RatsWilliam J. Banz0April D. Strader1Kolapo M. Ajuwon2Yuqing Hou3Cal Y. Meyers4Jeremy E. Davis5Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901-4317, USAPhysiology, Southern Illinois University, Carbondale, IL 62901-6512, USADepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907-2054, USADepartment of Chemistry and Biochemistry, Meyers Institute for Interdisciplinary Research in Organic and Medicinal Chemistry, Southern Illinois University, Carbondale, IL 62901-4409, USADepartment of Chemistry and Biochemistry, Meyers Institute for Interdisciplinary Research in Organic and Medicinal Chemistry, Southern Illinois University, Carbondale, IL 62901-4409, USADepartment of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901-4317, USAWe have previously reported that the synthetic estrogen, (+)-Z-bisdehydrodoisynolic Acid [(+)-Z-BDDA], attenuated weight gain and cardiovascular risk in obese rodents. To determine if these antiobesity effects were attributed to changes in basal metabolism, we assessed indirect calorimetry and metabolic profile in female obese Zucker (OZR) rats provided (+)-Z-BDDA (0.0002% food admixture) for 11 weeks. Similar to our previous findings, (+)-Z-BDDA reduced weight gain and improved lipid and glucose homeostasis in OZR rats. Furthermore, resting energy expenditure was increased by (+)-Z-BDDA, as evident by heat production and oxygen consumption. We also observed a marked reduction in respiratory quotient (RQ) along with a corresponding induction of hepatic AMPK in rodents provided (+)-Z-BDDA. Collectively, these findings indicate that (+)-Z-BDDA partially attenuated obesity and associated pathologies through increased resting energy expenditure and fatty acid utilization. Further investigation is required to fully elucidate the mechanisms involved as well as to determine the potential therapeutic implications for (+)-Z-BDDA on obesity and its related pathologies.http://dx.doi.org/10.1155/2012/154145 |
| spellingShingle | William J. Banz April D. Strader Kolapo M. Ajuwon Yuqing Hou Cal Y. Meyers Jeremy E. Davis (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats Journal of Obesity |
| title | (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats |
| title_full | (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats |
| title_fullStr | (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats |
| title_full_unstemmed | (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats |
| title_short | (+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats |
| title_sort | z bisdehydrodoisynolic acid enhances basal metabolism and fatty acid oxidation in female obese zucker rats |
| url | http://dx.doi.org/10.1155/2012/154145 |
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