Clinically relevant phenotypes in chronic rhinosinusitis
Abstract Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of CRS with and without nasal polyposis fails to adequately classify pa...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-05-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Online Access: | http://link.springer.com/article/10.1186/s40463-019-0350-y |
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| author | Jessica W. Grayson Marina Cavada Richard J. Harvey |
| author_facet | Jessica W. Grayson Marina Cavada Richard J. Harvey |
| author_sort | Jessica W. Grayson |
| collection | DOAJ |
| description | Abstract Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of CRS with and without nasal polyposis fails to adequately classify patients based upon their etiology of illness. Our aim with this review is discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary CRS: central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. Methods A narrative review of a tertiary rhinology center’s research themes and how they are applied to clinical protocols and practice was assessed. Discussion Diagnosis and treatment of upper and lower airway conditions become increasingly important as phenotypes and endotypes are being described. There are well-described therapies to treat the different phenotypes of CRS, based upon the presumed underlying cause of the inflammatory process. Research continues to shed more light on different endotypes and phenotypes of airway inflammation, however, clinical differentiation of CRS can be applied in clinic practice with three simple phenotypes of CRS. Understanding these different phenotypes and their etiologies allows for further management beyond the ‘maximum medical therapy and then surgery’ approach that has often been used in the management of CRS. |
| format | Article |
| id | doaj-art-abdeee8281ae4697bd21e193fab87c3f |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-abdeee8281ae4697bd21e193fab87c3f2025-02-03T10:54:12ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162019-05-0148111010.1186/s40463-019-0350-yClinically relevant phenotypes in chronic rhinosinusitisJessica W. Grayson0Marina Cavada1Richard J. Harvey2Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, University of New South WalesRhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, University of New South WalesRhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, University of New South WalesAbstract Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of CRS with and without nasal polyposis fails to adequately classify patients based upon their etiology of illness. Our aim with this review is discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary CRS: central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. Methods A narrative review of a tertiary rhinology center’s research themes and how they are applied to clinical protocols and practice was assessed. Discussion Diagnosis and treatment of upper and lower airway conditions become increasingly important as phenotypes and endotypes are being described. There are well-described therapies to treat the different phenotypes of CRS, based upon the presumed underlying cause of the inflammatory process. Research continues to shed more light on different endotypes and phenotypes of airway inflammation, however, clinical differentiation of CRS can be applied in clinic practice with three simple phenotypes of CRS. Understanding these different phenotypes and their etiologies allows for further management beyond the ‘maximum medical therapy and then surgery’ approach that has often been used in the management of CRS.http://link.springer.com/article/10.1186/s40463-019-0350-y |
| spellingShingle | Jessica W. Grayson Marina Cavada Richard J. Harvey Clinically relevant phenotypes in chronic rhinosinusitis Journal of Otolaryngology - Head and Neck Surgery |
| title | Clinically relevant phenotypes in chronic rhinosinusitis |
| title_full | Clinically relevant phenotypes in chronic rhinosinusitis |
| title_fullStr | Clinically relevant phenotypes in chronic rhinosinusitis |
| title_full_unstemmed | Clinically relevant phenotypes in chronic rhinosinusitis |
| title_short | Clinically relevant phenotypes in chronic rhinosinusitis |
| title_sort | clinically relevant phenotypes in chronic rhinosinusitis |
| url | http://link.springer.com/article/10.1186/s40463-019-0350-y |
| work_keys_str_mv | AT jessicawgrayson clinicallyrelevantphenotypesinchronicrhinosinusitis AT marinacavada clinicallyrelevantphenotypesinchronicrhinosinusitis AT richardjharvey clinicallyrelevantphenotypesinchronicrhinosinusitis |