The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Wnt/β-catenin signaling directs animal development and tissue renewal in a tightly controlled, cell- and tissue-specific manner. In the mammalian central nervous system, the atypical ligand Norrin controls angiogenesis and maintenance of the blood-brain barrier and blood-retina barrier through the W...

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Bibliographic Details
Main Authors: Elise S Bruguera, Jacob P Mahoney, William I Weis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
Wnt
cell signaling
specificity
co-receptor
nanodiscs
Online Access:https://elifesciences.org/articles/96743
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