Aberrant Alternative Splicing Is Another Hallmark of Cancer
The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/463786 |
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| _version_ | 1832565048364498944 |
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| author | Michael Ladomery |
| author_facet | Michael Ladomery |
| author_sort | Michael Ladomery |
| collection | DOAJ |
| description | The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases in cancer changes the alternative splicing of critically important pre-mRNAs. Aberrant alternative splicing should be added to the growing list of cancer hallmarks. |
| format | Article |
| id | doaj-art-abdd2d9a07354f1aa53b39277ff8d19c |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-abdd2d9a07354f1aa53b39277ff8d19c2025-02-03T01:09:34ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/463786463786Aberrant Alternative Splicing Is Another Hallmark of CancerMichael Ladomery0Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UKThe vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases in cancer changes the alternative splicing of critically important pre-mRNAs. Aberrant alternative splicing should be added to the growing list of cancer hallmarks.http://dx.doi.org/10.1155/2013/463786 |
| spellingShingle | Michael Ladomery Aberrant Alternative Splicing Is Another Hallmark of Cancer International Journal of Cell Biology |
| title | Aberrant Alternative Splicing Is Another Hallmark of Cancer |
| title_full | Aberrant Alternative Splicing Is Another Hallmark of Cancer |
| title_fullStr | Aberrant Alternative Splicing Is Another Hallmark of Cancer |
| title_full_unstemmed | Aberrant Alternative Splicing Is Another Hallmark of Cancer |
| title_short | Aberrant Alternative Splicing Is Another Hallmark of Cancer |
| title_sort | aberrant alternative splicing is another hallmark of cancer |
| url | http://dx.doi.org/10.1155/2013/463786 |
| work_keys_str_mv | AT michaelladomery aberrantalternativesplicingisanotherhallmarkofcancer |