Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery
Abstract Plant-derived nanovesicles (PDVs) as nanodrug delivery carriers have gained recognition due to their satisfactory biosafety. However, there remains a challenge to target tumor sites accurately due to the uncertain membrane protein components on the surface of vesicles. Herein, a composite n...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-025-03161-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571322746535936 |
|---|---|
| author | Lu-Yao Yang Guo-Wu Liang Bing-Jie Cai Ke-Min Xu Yu-Jie Zhao Xiao-Ting Xie Yu-Lin Zhang Chao-Qing Li Guo-Jun Zhang |
| author_facet | Lu-Yao Yang Guo-Wu Liang Bing-Jie Cai Ke-Min Xu Yu-Jie Zhao Xiao-Ting Xie Yu-Lin Zhang Chao-Qing Li Guo-Jun Zhang |
| author_sort | Lu-Yao Yang |
| collection | DOAJ |
| description | Abstract Plant-derived nanovesicles (PDVs) as nanodrug delivery carriers have gained recognition due to their satisfactory biosafety. However, there remains a challenge to target tumor sites accurately due to the uncertain membrane protein components on the surface of vesicles. Herein, a composite nanodrug delivery system by encapsulating the chemotherapy drug DOX is establish to efficiently target breast cancer. The novel nanoplatform (LEVBD) is formed by embedding the membrane fragments from breast cancer cell with the lemon-derived nanovesicles (LEVs) as the foundational skeleton. LEVBD reveal wonderful homologous tumor targeting due to fusion of cancer cell membrane components with LEVs, and the encapsulation of hybrid vesicles facilitates the transcellular transport of drugs. After intravenous injection, LEVBD could efficiently and selectively home to homologous tumor sites even under competition from heterologous tumors and significantly inhibit tumor growth without any observable toxic side effects. The doping of homologous cancer cell membranes provides a paradigm for the precise delivery of drug delivery vehicles using plant-derived vesicles as the backbone. Graphical abstract |
| format | Article |
| id | doaj-art-abd2c724fde3478395b113bd3f760e80 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-abd2c724fde3478395b113bd3f760e802025-02-02T12:41:14ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123111410.1186/s12951-025-03161-zEnhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug deliveryLu-Yao Yang0Guo-Wu Liang1Bing-Jie Cai2Ke-Min Xu3Yu-Jie Zhao4Xiao-Ting Xie5Yu-Lin Zhang6Chao-Qing Li7Guo-Jun Zhang8School of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineSchool of Laboratory Medicine, Hubei University of Chinese MedicineAbstract Plant-derived nanovesicles (PDVs) as nanodrug delivery carriers have gained recognition due to their satisfactory biosafety. However, there remains a challenge to target tumor sites accurately due to the uncertain membrane protein components on the surface of vesicles. Herein, a composite nanodrug delivery system by encapsulating the chemotherapy drug DOX is establish to efficiently target breast cancer. The novel nanoplatform (LEVBD) is formed by embedding the membrane fragments from breast cancer cell with the lemon-derived nanovesicles (LEVs) as the foundational skeleton. LEVBD reveal wonderful homologous tumor targeting due to fusion of cancer cell membrane components with LEVs, and the encapsulation of hybrid vesicles facilitates the transcellular transport of drugs. After intravenous injection, LEVBD could efficiently and selectively home to homologous tumor sites even under competition from heterologous tumors and significantly inhibit tumor growth without any observable toxic side effects. The doping of homologous cancer cell membranes provides a paradigm for the precise delivery of drug delivery vehicles using plant-derived vesicles as the backbone. Graphical abstracthttps://doi.org/10.1186/s12951-025-03161-zPlant-derived nanovesiclesCancer cell membraneHomologous targetingNanodrug delivery systemTumor therapy |
| spellingShingle | Lu-Yao Yang Guo-Wu Liang Bing-Jie Cai Ke-Min Xu Yu-Jie Zhao Xiao-Ting Xie Yu-Lin Zhang Chao-Qing Li Guo-Jun Zhang Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery Journal of Nanobiotechnology Plant-derived nanovesicles Cancer cell membrane Homologous targeting Nanodrug delivery system Tumor therapy |
| title | Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery |
| title_full | Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery |
| title_fullStr | Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery |
| title_full_unstemmed | Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery |
| title_short | Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery |
| title_sort | enhanced tumor self targeting of lemon derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery |
| topic | Plant-derived nanovesicles Cancer cell membrane Homologous targeting Nanodrug delivery system Tumor therapy |
| url | https://doi.org/10.1186/s12951-025-03161-z |
| work_keys_str_mv | AT luyaoyang enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT guowuliang enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT bingjiecai enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT keminxu enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT yujiezhao enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT xiaotingxie enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT yulinzhang enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT chaoqingli enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery AT guojunzhang enhancedtumorselftargetingoflemonderivedextracellularvesiclesbyembeddinghomotypiccancercellmembranesforefficientdrugdelivery |