Cervical poorly differentiated adenocarcinoma with dominant choriocarcinomatous pattern: A case report
Introduction. Gestational trophoblastic neoplasm (GTN), choriocarcinoma in coexistence with primary cervical adenocarcinoma, is a rare event not easy to diagnose. Choriocarcinoma is a malignant form of GTN but curable if metastases do not appear early and spread fast. Case report. We presen...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500041N.pdf |
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| Summary: | Introduction. Gestational trophoblastic neoplasm (GTN), choriocarcinoma in
coexistence with primary cervical adenocarcinoma, is a rare event not easy
to diagnose. Choriocarcinoma is a malignant form of GTN but curable if
metastases do not appear early and spread fast. Case report. We presented
choriocarcinoma in coexistence with primary cervical adenocarcinoma in a
48-year-old patient who had radical hysterectomy because of confirmed
cervical carcinoma (Dg: Carcinoma porto vaginalis uteri FIGO st I B1).
Histological findings confirmed cervical choriocarcinoma with extensive
vascular invasion and apoptosis but GTN choriocarcinoma was finally confirmed
after immunohystochemical examinations. Preoperative serum human
gonadotropine (beta hCG) level stayed unknown. This patient did not have any
pregnancy-like symptoms before the operation. The first beta hCG monitoring
was done two months after the operation and found negative. According to the
final diagnosis the decision of Consilium for Malignant Diseases was that
this patient needed serum hCG monitoring as well as treatment with
chemotherapy for high-risk GTN and consequent irradiation for adenocarcinoma.
Conclusion. The early and proper diagnosis of nonmetastatic choriocarcinoma
of nongestational origine in coexistence with cervical carcinoma is curable
and can have good prognosis. |
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| ISSN: | 0042-8450 |