Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia

This study is aimed at investigating the effects of shikonin, a pyruvate kinase M2 (PKM2) inhibitor, on the functions of myeloid dendritic cells (mDCs) in a mouse model of severe aplastic anemia (AA) generated by total body irradiation and lymphocyte infusion. Flow cytometry and qPCR were used to de...

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Bibliographic Details
Main Authors: Mengying Zheng, Bingnan Liu, Yuanyuan Shao, Luogang Hua, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao, Chunyan Liu
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2020/9025705
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