Study of 14-3-3 η eta protein in juvenile idiopathic arthritis
Abstract Background Juvenile idiopathic arthritis (JIA) refers to all types of arthritis that begin before the age of 16 and last more than 6 weeks, with no known cause. The 14-3-3 η eta protein is a new biomarker linked to the development of rheumatoid arthritis and joint destruction. We sought to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-06-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-025-00338-0 |
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| Summary: | Abstract Background Juvenile idiopathic arthritis (JIA) refers to all types of arthritis that begin before the age of 16 and last more than 6 weeks, with no known cause. The 14-3-3 η eta protein is a new biomarker linked to the development of rheumatoid arthritis and joint destruction. We sought to evaluate the 14-3-3 η eta protein’s potential as a diagnostic biomarker for JIA and its correlation with both functional outcome and disease activity. Results Significant levels of 14-3-3 η eta protein were found in rheumatoid factor (RF)-positive polyarticular JIA and RF-negative polyarticular JIA patients. Enthesitis-related arthritis (ERA) is associated with the lowest value of 14-3-3 η eta. 14-3-3 eta protein was significantly positively linked with CHAQ and JADAS 27 (p = 0.008 & 0.001, respectively). Conclusion The 14-3-3 η eta protein could be used as a biomarker to diagnose and monitor JIA. Significant levels of 14-3-3 η eta protein can be found in RF-positive polyarticular JIA and RF-negative polyarticular JIA patients. The 14-3-3 η eta protein correlates positively with disease activity and functional outcome in JIA. |
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| ISSN: | 2090-3235 |