Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications
In recent years, the incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide, in the context of an increasing prevalence of non-alcoholic fatty liver disease (NAFLD). In patients with diabetes mellitus, exogenous insulin is commonly prescribed and used in lon...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2024-04-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | http://www.actamedindones.org/index.php/ijim/article/view/2480 |
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| author | Juferdy Kurniawan Maria Teressa |
| author_facet | Juferdy Kurniawan Maria Teressa |
| author_sort | Juferdy Kurniawan |
| collection | DOAJ |
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In recent years, the incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide, in the context of an increasing prevalence of non-alcoholic fatty liver disease (NAFLD). In patients with diabetes mellitus, exogenous insulin is commonly prescribed and used in long-term settings. Recent studies suggest that insulin use may elevate the risk of HCC. A substantial body of work seeks to unpack the association between insulin use and the risk of developing HCC, although there may be conflicting evidence. Further validation is necessary to clarify the true relationship between insulin mechanisms and its hepatocarcinogenic effect. Given the burden of diabetic patients developing HCC, diabetologists and hepatologists must collaborate, particularly regarding the prevention and surveillance of HCC in diabetic patients.
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| format | Article |
| id | doaj-art-abc5f19a787040fb87f751a16decd160 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-abc5f19a787040fb87f751a16decd1602025-08-20T03:27:18ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322024-04-01561Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and ImplicationsJuferdy Kurniawan0Maria Teressa1Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia In recent years, the incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide, in the context of an increasing prevalence of non-alcoholic fatty liver disease (NAFLD). In patients with diabetes mellitus, exogenous insulin is commonly prescribed and used in long-term settings. Recent studies suggest that insulin use may elevate the risk of HCC. A substantial body of work seeks to unpack the association between insulin use and the risk of developing HCC, although there may be conflicting evidence. Further validation is necessary to clarify the true relationship between insulin mechanisms and its hepatocarcinogenic effect. Given the burden of diabetic patients developing HCC, diabetologists and hepatologists must collaborate, particularly regarding the prevention and surveillance of HCC in diabetic patients. http://www.actamedindones.org/index.php/ijim/article/view/2480hepatocellular carcinomainsulininsulin userisk |
| spellingShingle | Juferdy Kurniawan Maria Teressa Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications Acta Medica Indonesiana hepatocellular carcinoma insulin insulin use risk |
| title | Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications |
| title_full | Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications |
| title_fullStr | Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications |
| title_full_unstemmed | Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications |
| title_short | Insulin Use and The Risk of Hepatocellular Carcinoma: Insights and Implications |
| title_sort | insulin use and the risk of hepatocellular carcinoma insights and implications |
| topic | hepatocellular carcinoma insulin insulin use risk |
| url | http://www.actamedindones.org/index.php/ijim/article/view/2480 |
| work_keys_str_mv | AT juferdykurniawan insulinuseandtheriskofhepatocellularcarcinomainsightsandimplications AT mariateressa insulinuseandtheriskofhepatocellularcarcinomainsightsandimplications |