Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems
Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mi...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0008 |
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| author | Casanova Yaquelyn Negro Sofia Barcia Emilia |
| author_facet | Casanova Yaquelyn Negro Sofia Barcia Emilia |
| author_sort | Casanova Yaquelyn |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mine contents of the caudate-putamen structures. To this date, there is no cure for the disease and available treatments are aimed at controlling the symptoms. Therefore, there is an unmet need for new treatments for PD. In the past decades, animal models of PD have been proven to be valuable tools in elucidating the nature of the pathogenic processes involved in the disease, and in designing new pharmacological approaches. Here, we review the use of neurotoxin-induced and pesticide-induced animal models of PD, specifically those induced by rotenone, paraquat, maneb, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-OHDA (6-hydroxydopamine), and their application in the development of new drug delivery systems for PD. |
| format | Article |
| id | doaj-art-abbfe063ed5440c48b1867cc97f5546c |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-abbfe063ed5440c48b1867cc97f5546c2025-02-02T02:10:55ZengSciendoActa Pharmaceutica1846-95582022-03-01721355810.2478/acph-2022-0008Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systemsCasanova Yaquelyn0Negro Sofia1Barcia Emilia2Department of Pharmaceutics and Food Technology, School of Pharmacy Universidad Complutense de MadridMadrid, SpainDepartment of Pharmaceutics and Food Technology, School of Pharmacy Universidad Complutense de MadridMadrid, SpainDepartment of Pharmaceutics and Food Technology, School of Pharmacy Universidad Complutense de MadridMadrid, SpainParkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mine contents of the caudate-putamen structures. To this date, there is no cure for the disease and available treatments are aimed at controlling the symptoms. Therefore, there is an unmet need for new treatments for PD. In the past decades, animal models of PD have been proven to be valuable tools in elucidating the nature of the pathogenic processes involved in the disease, and in designing new pharmacological approaches. Here, we review the use of neurotoxin-induced and pesticide-induced animal models of PD, specifically those induced by rotenone, paraquat, maneb, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-OHDA (6-hydroxydopamine), and their application in the development of new drug delivery systems for PD.https://doi.org/10.2478/acph-2022-0008parkinson’s diseaserotenoneparaquatmanebmptp6-ohdaanimal modelcontrolled drug delivery |
| spellingShingle | Casanova Yaquelyn Negro Sofia Barcia Emilia Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems Acta Pharmaceutica parkinson’s disease rotenone paraquat maneb mptp 6-ohda animal model controlled drug delivery |
| title | Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems |
| title_full | Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems |
| title_fullStr | Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems |
| title_full_unstemmed | Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems |
| title_short | Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems |
| title_sort | application of neurotoxin and pesticide induced animal models of parkinson s disease in the evaluation of new drug delivery systems |
| topic | parkinson’s disease rotenone paraquat maneb mptp 6-ohda animal model controlled drug delivery |
| url | https://doi.org/10.2478/acph-2022-0008 |
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