Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats
In the current study, it was hypothesized that the addition of strawberry polyphenol-rich fractions to a high-fructose diet mitigates disorders in liver functions, lipid metabolism, and in the antioxidant and pro-inflammatory status of rats. Therefore, a fraction rich in ellagitannins and proanthocy...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2021-11-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://journal.pan.olsztyn.pl/Strawberry-Polyphenol-Rich-Fractions-Can-Mitigate-Disorders-in-Gastrointestinal-Tract,143057,0,2.html |
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| author | Ewa Żary-Sikorska Bartosz Fotschki Monika Kosmala Joanna Milala Paulius Matusevicius Aleksandra Rawicka Jerzy Juśkiewicz |
| author_facet | Ewa Żary-Sikorska Bartosz Fotschki Monika Kosmala Joanna Milala Paulius Matusevicius Aleksandra Rawicka Jerzy Juśkiewicz |
| author_sort | Ewa Żary-Sikorska |
| collection | DOAJ |
| description | In the current study, it was hypothesized that the addition of strawberry polyphenol-rich fractions to a high-fructose diet mitigates disorders in liver functions, lipid metabolism, and in the antioxidant and pro-inflammatory status of rats. Therefore, a fraction rich in ellagitannins and proanthocyanidins (EP), and a fraction containing compounds of both mentioned classes of polyphenols and additionally anthocyanins (EPA), in doses of 0.28 and 0.70 g/100 g, respectively, were added to a standard or a high-fructose diet administered to rats for six weeks. The EPA fraction was more beneficial in alleviating the consequences of consuming excess fructose in the diet than the EP fraction. Probably, that fraction containing considerable amounts of carbohydrates was more extensively metabolized by intestinal bacteria, which resulted in higher levels of cecal short chain fatty acids (SCFAs) as well as cecal and urinal ellagitannin metabolites. As a further consequence, diet supplementation with the EPA fraction caused more favorable changes in the levels of serum interleukin 6 and serum antioxidant capacity of water-soluble substances (ACW), in atherogenicity index lg((triglyceride/high-density lipoprotein cholesterol), hepatic oxidized glutathione as well as reduced to oxidized glutathione ratio). Efforts should be made to develop strawberry polyphenol-rich preparations containing the preferred anthocyanins, which is, however, difficult due to the instability of this class of phenolic compounds during the technological process. |
| format | Article |
| id | doaj-art-abbe9bc210554253995cb4bd92f6a61c |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-abbe9bc210554253995cb4bd92f6a61c2025-02-02T12:29:41ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072021-11-0171442344010.31883/pjfns/143057143057Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental RatsEwa Żary-Sikorska0https://orcid.org/0000-0001-8140-3861Bartosz Fotschki1https://orcid.org/0000-0002-9727-7481Monika Kosmala2https://orcid.org/0000-0002-9018-3028Joanna Milala3https://orcid.org/0000-0002-4732-1907Paulius Matusevicius4https://orcid.org/0000-0002-6612-2479Aleksandra Rawicka5Jerzy Juśkiewicz6https://orcid.org/0000-0003-0068-5970Department of Microbiology and Food Technology, Faculty of Agriculture and Biotechnology, Bydgoszcz University of Science and Technology, Kaliskiego 7, 85–796 Bydgoszcz, PolandDepartment of Biological Functions of Food, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10–748 Olsztyn, PolandInstitute of Food Technology and Analysis, Łódź University of Technology, Stefanowskiego 4/10, 90–924 Łódź, PolandInstitute of Food Technology and Analysis, Łódź University of Technology, Stefanowskiego 4/10, 90–924 Łódź, PolandDepartment of Animal Nutrition, Lithuanian University of Health, Kaunas, Tilzes 18, LT-47181 Kaunas, LithuaniaPoliclinico Veterinario Roma Sud, Ophthalmology, 00173 Rome, ItalyDepartment of Biological Functions of Food, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10–748 Olsztyn, PolandIn the current study, it was hypothesized that the addition of strawberry polyphenol-rich fractions to a high-fructose diet mitigates disorders in liver functions, lipid metabolism, and in the antioxidant and pro-inflammatory status of rats. Therefore, a fraction rich in ellagitannins and proanthocyanidins (EP), and a fraction containing compounds of both mentioned classes of polyphenols and additionally anthocyanins (EPA), in doses of 0.28 and 0.70 g/100 g, respectively, were added to a standard or a high-fructose diet administered to rats for six weeks. The EPA fraction was more beneficial in alleviating the consequences of consuming excess fructose in the diet than the EP fraction. Probably, that fraction containing considerable amounts of carbohydrates was more extensively metabolized by intestinal bacteria, which resulted in higher levels of cecal short chain fatty acids (SCFAs) as well as cecal and urinal ellagitannin metabolites. As a further consequence, diet supplementation with the EPA fraction caused more favorable changes in the levels of serum interleukin 6 and serum antioxidant capacity of water-soluble substances (ACW), in atherogenicity index lg((triglyceride/high-density lipoprotein cholesterol), hepatic oxidized glutathione as well as reduced to oxidized glutathione ratio). Efforts should be made to develop strawberry polyphenol-rich preparations containing the preferred anthocyanins, which is, however, difficult due to the instability of this class of phenolic compounds during the technological process.http://journal.pan.olsztyn.pl/Strawberry-Polyphenol-Rich-Fractions-Can-Mitigate-Disorders-in-Gastrointestinal-Tract,143057,0,2.htmlrat modelstrawberrybioactive compoundsanthocyaninsellagitanninsgastrointestinal tract |
| spellingShingle | Ewa Żary-Sikorska Bartosz Fotschki Monika Kosmala Joanna Milala Paulius Matusevicius Aleksandra Rawicka Jerzy Juśkiewicz Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats Polish Journal of Food and Nutrition Sciences rat model strawberry bioactive compounds anthocyanins ellagitannins gastrointestinal tract |
| title | Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats |
| title_full | Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats |
| title_fullStr | Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats |
| title_full_unstemmed | Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats |
| title_short | Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats |
| title_sort | strawberry polyphenol rich fractions can mitigate disorders in gastrointestinal tract and liver functions caused by a high fructose diet in experimental rats |
| topic | rat model strawberry bioactive compounds anthocyanins ellagitannins gastrointestinal tract |
| url | http://journal.pan.olsztyn.pl/Strawberry-Polyphenol-Rich-Fractions-Can-Mitigate-Disorders-in-Gastrointestinal-Tract,143057,0,2.html |
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