MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India
Abstract Hepatic fibrosis is a critical complication of metabolic disorders, particularly in patients with Type 2 Diabetes (T2D). This study aimed to evaluate the performance of the Fibrosis 4 index (FIB 4) score in detecting significant fibrosis (transient elastography [TE] ≥ 8 kPa) and identify ke...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-10871-9 |
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| author | Debasis Datta Krishna G. Seshadri Samit Ghosal |
| author_facet | Debasis Datta Krishna G. Seshadri Samit Ghosal |
| author_sort | Debasis Datta |
| collection | DOAJ |
| description | Abstract Hepatic fibrosis is a critical complication of metabolic disorders, particularly in patients with Type 2 Diabetes (T2D). This study aimed to evaluate the performance of the Fibrosis 4 index (FIB 4) score in detecting significant fibrosis (transient elastography [TE] ≥ 8 kPa) and identify key predictors of significant fibrosis using logistic regression analysis in patients with T2D. This cross-sectional study, conducted across three tertiary care centres in India, prospectively enrolled and propensity-matched T2D and non-T2D patients to balance cohorts, resulting in a final analysis cohort of 472 patients (236 T2D, 236 non-T2D). Sensitivity, specificity, and Cohen’s Kappa were used to assess agreement between FIB 4 score ≥ 1.3 and TE ≥ 8 kPa. Logistic regression models were used to identify independent predictors of significant fibrosis. The predictive performance of the models was evaluated using ROC curves. The FIB 4 score demonstrated high sensitivity (85.3%) but low specificity (13.7%) in the T2D cohort, with a Cohen’s Kappa of -0.01, indicating no agreement with TE. In the non-T2D cohort, specificity improved to 47.2% with a Cohen’s Kappa of 0.16. Logistic regression identified BMI, hypertension, and HbA1c as significant predictors of hepatic fibrosis in T2D patients, with odds ratios of 1.076, 1.824, and 1.279, respectively. Male sex, BMI, AST, and HbA1c were retained in the refined multivariate model, achieving an AUC of 0.735, indicating good discriminatory ability. Elevated transaminases were weakly associated with fibrosis, while BMI and HbA1c showed stronger associations. While FIB 4 is sensitive for detecting significant fibrosis, its low specificity limits its utility as a standalone diagnostic test, particularly in T2D patients. Logistic regression highlighted BMI, AST, and HbA1c as key predictors of fibrosis, emphasising the need to combine non-invasive tools with clinical variables for more accurate risk stratification and improved management of MASLD. Future research should focus on refining diagnostic algorithms to better address the burden of significant fibrosis in at-risk populations. |
| format | Article |
| id | doaj-art-abb18beb9e914dea89ba7639b43baefa |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-abb18beb9e914dea89ba7639b43baefa2025-08-20T03:05:22ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-10871-9MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in IndiaDebasis Datta0Krishna G. Seshadri1Samit Ghosal2Fortis HospitalApollo HospitalNightingale HospitalAbstract Hepatic fibrosis is a critical complication of metabolic disorders, particularly in patients with Type 2 Diabetes (T2D). This study aimed to evaluate the performance of the Fibrosis 4 index (FIB 4) score in detecting significant fibrosis (transient elastography [TE] ≥ 8 kPa) and identify key predictors of significant fibrosis using logistic regression analysis in patients with T2D. This cross-sectional study, conducted across three tertiary care centres in India, prospectively enrolled and propensity-matched T2D and non-T2D patients to balance cohorts, resulting in a final analysis cohort of 472 patients (236 T2D, 236 non-T2D). Sensitivity, specificity, and Cohen’s Kappa were used to assess agreement between FIB 4 score ≥ 1.3 and TE ≥ 8 kPa. Logistic regression models were used to identify independent predictors of significant fibrosis. The predictive performance of the models was evaluated using ROC curves. The FIB 4 score demonstrated high sensitivity (85.3%) but low specificity (13.7%) in the T2D cohort, with a Cohen’s Kappa of -0.01, indicating no agreement with TE. In the non-T2D cohort, specificity improved to 47.2% with a Cohen’s Kappa of 0.16. Logistic regression identified BMI, hypertension, and HbA1c as significant predictors of hepatic fibrosis in T2D patients, with odds ratios of 1.076, 1.824, and 1.279, respectively. Male sex, BMI, AST, and HbA1c were retained in the refined multivariate model, achieving an AUC of 0.735, indicating good discriminatory ability. Elevated transaminases were weakly associated with fibrosis, while BMI and HbA1c showed stronger associations. While FIB 4 is sensitive for detecting significant fibrosis, its low specificity limits its utility as a standalone diagnostic test, particularly in T2D patients. Logistic regression highlighted BMI, AST, and HbA1c as key predictors of fibrosis, emphasising the need to combine non-invasive tools with clinical variables for more accurate risk stratification and improved management of MASLD. Future research should focus on refining diagnostic algorithms to better address the burden of significant fibrosis in at-risk populations.https://doi.org/10.1038/s41598-025-10871-9MASLDT2DCross-sectional studyFIB 4Transient elastography |
| spellingShingle | Debasis Datta Krishna G. Seshadri Samit Ghosal MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India Scientific Reports MASLD T2D Cross-sectional study FIB 4 Transient elastography |
| title | MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India |
| title_full | MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India |
| title_fullStr | MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India |
| title_full_unstemmed | MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India |
| title_short | MISHTI study evaluating hepatic fibrosis in type 2 diabetes patients in India |
| title_sort | mishti study evaluating hepatic fibrosis in type 2 diabetes patients in india |
| topic | MASLD T2D Cross-sectional study FIB 4 Transient elastography |
| url | https://doi.org/10.1038/s41598-025-10871-9 |
| work_keys_str_mv | AT debasisdatta mishtistudyevaluatinghepaticfibrosisintype2diabetespatientsinindia AT krishnagseshadri mishtistudyevaluatinghepaticfibrosisintype2diabetespatientsinindia AT samitghosal mishtistudyevaluatinghepaticfibrosisintype2diabetespatientsinindia |