Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation
Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/167572 |
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| author | Yue Sun Dejing Shang |
| author_facet | Yue Sun Dejing Shang |
| author_sort | Yue Sun |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activities and specific antimicrobial mechanism. Besides broad-spectrum antibacterial activity, AMPs also have anti-inflammatory activity. The neutralization of lipopolysaccharides (LPS) plays a key role in anti-inflammatory action of AMPs. On the one hand, AMPs can readily penetrate the cell wall barrier by neutralizing LPS to remove Gram-negative bacteria that can lead to infection. On the contrary, AMPs can also inhibit the production of biological inflammatory cytokines to reduce the inflammatory response through neutralizing circulating LPS. In addition, AMPs also modulate the host immune system by chemotaxis of leukocytes, to promote immune cell proliferation, epithelialization, and angiogenesis and thus play a protective role. This review summarizes some recent researches about anti-inflammatory AMPs, with a focus on the interaction of AMPs and LPS on the past decade. |
| format | Article |
| id | doaj-art-aba0a676fb8a479b9bd6bca250a2470a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-aba0a676fb8a479b9bd6bca250a2470a2025-02-03T01:09:12ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/167572167572Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced InflammationYue Sun0Dejing Shang1School of Life Science, Liaoning Normal University, Dalian 116081, ChinaSchool of Life Science, Liaoning Normal University, Dalian 116081, ChinaAntimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activities and specific antimicrobial mechanism. Besides broad-spectrum antibacterial activity, AMPs also have anti-inflammatory activity. The neutralization of lipopolysaccharides (LPS) plays a key role in anti-inflammatory action of AMPs. On the one hand, AMPs can readily penetrate the cell wall barrier by neutralizing LPS to remove Gram-negative bacteria that can lead to infection. On the contrary, AMPs can also inhibit the production of biological inflammatory cytokines to reduce the inflammatory response through neutralizing circulating LPS. In addition, AMPs also modulate the host immune system by chemotaxis of leukocytes, to promote immune cell proliferation, epithelialization, and angiogenesis and thus play a protective role. This review summarizes some recent researches about anti-inflammatory AMPs, with a focus on the interaction of AMPs and LPS on the past decade.http://dx.doi.org/10.1155/2015/167572 |
| spellingShingle | Yue Sun Dejing Shang Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation Mediators of Inflammation |
| title | Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation |
| title_full | Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation |
| title_fullStr | Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation |
| title_full_unstemmed | Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation |
| title_short | Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation |
| title_sort | inhibitory effects of antimicrobial peptides on lipopolysaccharide induced inflammation |
| url | http://dx.doi.org/10.1155/2015/167572 |
| work_keys_str_mv | AT yuesun inhibitoryeffectsofantimicrobialpeptidesonlipopolysaccharideinducedinflammation AT dejingshang inhibitoryeffectsofantimicrobialpeptidesonlipopolysaccharideinducedinflammation |