Association Between Synovial NTN4 Expression and Pain Scores, and Its Effects on Fibroblasts and Sensory Neurons in End-Stage Knee Osteoarthritis

Association Between Synovial NTN4 Expression and Pain Scores, and Its Effects on Fibroblasts and Sensory Neurons in End-Stage Knee Osteoarthritis

Osteoarthritis (OA) is a chronic joint disease marked by synovial inflammation, cartilage degradation, and persistent pain. Although Netrin-4 (NTN4) has been implicated in pain modulation in rheumatoid arthritis (RA), its role in OA pain remains less understood. Previous research has documented that...

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Bibliographic Details
Main Authors: Ayumi Tsukada, Yui Uekusa, Etsuro Ohta, Akito Hattori, Manabu Mukai, Dai Iwase, Jun Aikawa, Yoshihisa Ohashi, Gen Inoue, Masashi Takaso, Kentaro Uchida
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
osteoarthritis
netrin-4
synovium
sensory neuron
fibroblast
Online Access:https://www.mdpi.com/2073-4409/14/6/395
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