Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor
The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs). ZEB1 (also known as δEF1, zfhx1...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/903918 |
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| _version_ | 1832559506355126272 |
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| author | Bynthia M. Anose Michel M. Sanders |
| author_facet | Bynthia M. Anose Michel M. Sanders |
| author_sort | Bynthia M. Anose |
| collection | DOAJ |
| description | The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs). ZEB1 (also known as δEF1, zfhx1a, TCF8, and Zfhep) plays a key role in regulating such diverse processes as T-cell development, skeletal patterning, reproduction, and cancer cell metastasis. However, the factors that regulate its expression and consequently the signaling pathways in which ZEB1 participates are poorly defined. Because it is induced by estrogen and progesterone and is high in prostate cancer, we investigated whether tcf8, which encodes ZEB1, is regulated by androgen. Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs). These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways. |
| format | Article |
| id | doaj-art-aba030165af34c29841d32c861b8d9ad |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-aba030165af34c29841d32c861b8d9ad2025-02-03T01:29:55ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/903918903918Androgen Receptor Regulates Transcription of the ZEB1 Transcription FactorBynthia M. Anose0Michel M. Sanders1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USADepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USAThe zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs). ZEB1 (also known as δEF1, zfhx1a, TCF8, and Zfhep) plays a key role in regulating such diverse processes as T-cell development, skeletal patterning, reproduction, and cancer cell metastasis. However, the factors that regulate its expression and consequently the signaling pathways in which ZEB1 participates are poorly defined. Because it is induced by estrogen and progesterone and is high in prostate cancer, we investigated whether tcf8, which encodes ZEB1, is regulated by androgen. Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs). These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways.http://dx.doi.org/10.1155/2011/903918 |
| spellingShingle | Bynthia M. Anose Michel M. Sanders Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor International Journal of Endocrinology |
| title | Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor |
| title_full | Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor |
| title_fullStr | Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor |
| title_full_unstemmed | Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor |
| title_short | Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor |
| title_sort | androgen receptor regulates transcription of the zeb1 transcription factor |
| url | http://dx.doi.org/10.1155/2011/903918 |
| work_keys_str_mv | AT bynthiamanose androgenreceptorregulatestranscriptionofthezeb1transcriptionfactor AT michelmsanders androgenreceptorregulatestranscriptionofthezeb1transcriptionfactor |