Effect of D-penicillamine on Vitamin B6 Activation of Aspartate Aminotransferase in Synaptosomes of the Developing Brain
The activity of aspartate aminotransferase a vitamin B6 containing enzyme was measured in the laysed synaptosomes prepared from rat brain, during development. Administration of vitamin B6 increased the enzyme activity throughout development. The stimulating effect of this vitamin was prevented when...
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| Format: | Article |
|---|---|
| Language: | English |
| Published: |
University of Tehran
1989-12-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31166_93862c32fa88ed11081ab78e69f34891.pdf |
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| collection | DOAJ |
| description | The activity of aspartate aminotransferase a vitamin B6 containing enzyme
was measured in the laysed synaptosomes prepared from rat brain, during
development. Administration of vitamin B6 increased the enzyme activity
throughout development. The stimulating effect of this vitamin was prevented
when the animals were previously treated with D-penicillamine. However,
penicillamine alone had no effect on the pattern of the enzyme activity during
development. Similar results were observed when the synaptosomal preparations
were incubated in the presence of the vitamin, the drug or both. It is concluded that
vitamin B6 content of the brain might be unaffected by D-penicillamine treatment |
| format | Article |
| id | doaj-art-ab9e00560a7a427aa7ddcef8a2cdcee3 |
| institution | OA Journals |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 1989-12-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-ab9e00560a7a427aa7ddcef8a2cdcee32025-08-20T02:25:50ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69141989-12-011131166Effect of D-penicillamine on Vitamin B6 Activation of Aspartate Aminotransferase in Synaptosomes of the Developing BrainThe activity of aspartate aminotransferase a vitamin B6 containing enzyme was measured in the laysed synaptosomes prepared from rat brain, during development. Administration of vitamin B6 increased the enzyme activity throughout development. The stimulating effect of this vitamin was prevented when the animals were previously treated with D-penicillamine. However, penicillamine alone had no effect on the pattern of the enzyme activity during development. Similar results were observed when the synaptosomal preparations were incubated in the presence of the vitamin, the drug or both. It is concluded that vitamin B6 content of the brain might be unaffected by D-penicillamine treatmenthttps://jsciences.ut.ac.ir/article_31166_93862c32fa88ed11081ab78e69f34891.pdf |
| spellingShingle | Effect of D-penicillamine on Vitamin B6 Activation of Aspartate
Aminotransferase in Synaptosomes of the Developing Brain Journal of Sciences, Islamic Republic of Iran |
| title | Effect of D-penicillamine on Vitamin B6 Activation of Aspartate
Aminotransferase in Synaptosomes of the Developing Brain |
| title_full | Effect of D-penicillamine on Vitamin B6 Activation of Aspartate
Aminotransferase in Synaptosomes of the Developing Brain |
| title_fullStr | Effect of D-penicillamine on Vitamin B6 Activation of Aspartate
Aminotransferase in Synaptosomes of the Developing Brain |
| title_full_unstemmed | Effect of D-penicillamine on Vitamin B6 Activation of Aspartate
Aminotransferase in Synaptosomes of the Developing Brain |
| title_short | Effect of D-penicillamine on Vitamin B6 Activation of Aspartate
Aminotransferase in Synaptosomes of the Developing Brain |
| title_sort | effect of d penicillamine on vitamin b6 activation of aspartate aminotransferase in synaptosomes of the developing brain |
| url | https://jsciences.ut.ac.ir/article_31166_93862c32fa88ed11081ab78e69f34891.pdf |