Predictive role of MGMT and IDH status in the efficacy of bevacizumab for high-grade glioma: a retrospective study

Predictive role of MGMT and IDH status in the efficacy of bevacizumab for high-grade glioma: a retrospective study

BackgroundThe objective of this study is to investigate the predictive role of O6-methylguanine-DNA methyltransferase (MGMT) and isocitrate dehydrogenase (IDH) status on the efficacy of bevacizumab (BEV) in high-grade glioma (HGG), while excluding the interference of chemotherapy agents.MethodsA ret...

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Bibliographic Details
Main Authors: Bai Xuexue, Yan Chengrui, Wenbin Ma, Feng Ming, Wu Chao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
bevacizumab
high-grade glioma
MGMT
IDH
predictor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1634892/full
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