TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Geneti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/75 |
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| author | Gilmara Barros de Lima Everton Nencioni Fábio Thimoteo Camila Perea Rafaela Fuzaro Alves Pinto Sergio Daishi Sasaki |
| author_facet | Gilmara Barros de Lima Everton Nencioni Fábio Thimoteo Camila Perea Rafaela Fuzaro Alves Pinto Sergio Daishi Sasaki |
| author_sort | Gilmara Barros de Lima |
| collection | DOAJ |
| description | TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. As we uncover more about TMPRSS2’s role in pathogenesis, it could open new doors for therapies to combat future outbreaks. |
| format | Article |
| id | doaj-art-ab9c44815cfc480280ab15b738ea91b4 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-ab9c44815cfc480280ab15b738ea91b42025-01-24T13:25:05ZengMDPI AGBiomolecules2218-273X2025-01-011517510.3390/biom15010075TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and CoronavirusesGilmara Barros de Lima0Everton Nencioni1Fábio Thimoteo2Camila Perea3Rafaela Fuzaro Alves Pinto4Sergio Daishi Sasaki5Graduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, BrazilGraduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, BrazilGraduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, BrazilGraduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, BrazilGraduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, BrazilGraduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, BrazilTMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. As we uncover more about TMPRSS2’s role in pathogenesis, it could open new doors for therapies to combat future outbreaks.https://www.mdpi.com/2218-273X/15/1/75TMPRSS2serine proteinase inhibitorsinfluenzacoronavirus |
| spellingShingle | Gilmara Barros de Lima Everton Nencioni Fábio Thimoteo Camila Perea Rafaela Fuzaro Alves Pinto Sergio Daishi Sasaki TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses Biomolecules TMPRSS2 serine proteinase inhibitors influenza coronavirus |
| title | TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses |
| title_full | TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses |
| title_fullStr | TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses |
| title_full_unstemmed | TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses |
| title_short | TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses |
| title_sort | tmprss2 as a key player in viral pathogenesis influenza and coronaviruses |
| topic | TMPRSS2 serine proteinase inhibitors influenza coronavirus |
| url | https://www.mdpi.com/2218-273X/15/1/75 |
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