Gene Therapy for Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is a devastating, aggressive primary brain tumor with poor patient outcomes and a five-year survival of less than 10%. Significant limitations to effective GBM treatment include poor drug delivery across the blood–brain barrier, drug resistance, and complex genetic tumo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/118 |
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| author | Smit Shah Joshua Green Shantelle A. Graff Qi Li John D. Heiss |
| author_facet | Smit Shah Joshua Green Shantelle A. Graff Qi Li John D. Heiss |
| author_sort | Smit Shah |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is a devastating, aggressive primary brain tumor with poor patient outcomes and a five-year survival of less than 10%. Significant limitations to effective GBM treatment include poor drug delivery across the blood–brain barrier, drug resistance, and complex genetic tumor alterations. Gene therapy uses a mechanism different from other GBM therapies to reduce tumor growth and enhance antitumor immunity. This review article will provide an update on various viral and nonviral vectors, their DNA and RNA cargoes, and how they genetically modify tumor cells and evoke therapeutic responses to GBM. The article explores the oncolytic and immunogenic effects of gene therapy agents. It reviews promising DNA transgenes, RNA inhibitors, and vectors for anti-GBM therapy. The possible benefits of combining gene therapy with standard GBM treatments will also be covered. |
| format | Article |
| id | doaj-art-ab9aface0e984c9e9809c562ec4804d2 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-ab9aface0e984c9e9809c562ec4804d22025-01-24T13:52:39ZengMDPI AGViruses1999-49152025-01-0117111810.3390/v17010118Gene Therapy for Glioblastoma MultiformeSmit Shah0Joshua Green1Shantelle A. Graff2Qi Li3John D. Heiss4Neurology Department, School of Medicine, University of South Carolina, 15 Medical Park Rd., Columbia, SC 29203, USASurgical Neurology Branch, NINDS, NIH 10 Center Drive, Bethesda, MD 20892, USASurgical Neurology Branch, NINDS, NIH 10 Center Drive, Bethesda, MD 20892, USANeuro-Oncology Branch, CCR, NCI, NIH, 37 Convent Drive, Bethesda, MD 20892, USASurgical Neurology Branch, NINDS, NIH 10 Center Drive, Bethesda, MD 20892, USAGlioblastoma multiforme (GBM) is a devastating, aggressive primary brain tumor with poor patient outcomes and a five-year survival of less than 10%. Significant limitations to effective GBM treatment include poor drug delivery across the blood–brain barrier, drug resistance, and complex genetic tumor alterations. Gene therapy uses a mechanism different from other GBM therapies to reduce tumor growth and enhance antitumor immunity. This review article will provide an update on various viral and nonviral vectors, their DNA and RNA cargoes, and how they genetically modify tumor cells and evoke therapeutic responses to GBM. The article explores the oncolytic and immunogenic effects of gene therapy agents. It reviews promising DNA transgenes, RNA inhibitors, and vectors for anti-GBM therapy. The possible benefits of combining gene therapy with standard GBM treatments will also be covered.https://www.mdpi.com/1999-4915/17/1/118glioblastomagenetherapyvectorsurvival |
| spellingShingle | Smit Shah Joshua Green Shantelle A. Graff Qi Li John D. Heiss Gene Therapy for Glioblastoma Multiforme Viruses glioblastoma gene therapy vector survival |
| title | Gene Therapy for Glioblastoma Multiforme |
| title_full | Gene Therapy for Glioblastoma Multiforme |
| title_fullStr | Gene Therapy for Glioblastoma Multiforme |
| title_full_unstemmed | Gene Therapy for Glioblastoma Multiforme |
| title_short | Gene Therapy for Glioblastoma Multiforme |
| title_sort | gene therapy for glioblastoma multiforme |
| topic | glioblastoma gene therapy vector survival |
| url | https://www.mdpi.com/1999-4915/17/1/118 |
| work_keys_str_mv | AT smitshah genetherapyforglioblastomamultiforme AT joshuagreen genetherapyforglioblastomamultiforme AT shantelleagraff genetherapyforglioblastomamultiforme AT qili genetherapyforglioblastomamultiforme AT johndheiss genetherapyforglioblastomamultiforme |