Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease
We describe our experience with a juvenile patient who had refractory intestinal Behcet’s disease that responded to adalimumab, a fully humanized antibody against soluble TNF-α and its receptor. The patient, a 13-year-old girl, presented with oral aphthous ulcers, vulvar pain, and rashes on the lowe...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2015/716138 |
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| author | Mariko Kaji Takayuki Kishi Takako Miyamae Satoru Nagata Hisashi Yamanaka Satoshi Fujikawa |
| author_facet | Mariko Kaji Takayuki Kishi Takako Miyamae Satoru Nagata Hisashi Yamanaka Satoshi Fujikawa |
| author_sort | Mariko Kaji |
| collection | DOAJ |
| description | We describe our experience with a juvenile patient who had refractory intestinal Behcet’s disease that responded to adalimumab, a fully humanized antibody against soluble TNF-α and its receptor. The patient, a 13-year-old girl, presented with oral aphthous ulcers, vulvar pain, and rashes on the lower extremities. She gradually developed a low-grade fever, abdominal pain, diarrhea, and hematochezia. Lower gastrointestinal endoscopy revealed ulcers in the terminal ileum, consistent with intestinal Behcet’s disease. Methylprednisolone pulse therapy was initiated, after which the symptoms transiently improved, but, during the corticosteroid taper, the abdominal pain recurred. The symptoms resolved soon after the administration of adalimumab. Of importance, the dose of corticosteroids was successfully reduced without exacerbation during 8 months of observation. This is the first reported case in which adalimumab was used for pediatric gastrointestinal Behcet’s disease. Adalimumab is a good choice for intestinal Behcet’s disease refractory to conventional treatment. |
| format | Article |
| id | doaj-art-ab83e7aa795e499d9510aabdaa9b124a |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-ab83e7aa795e499d9510aabdaa9b124a2025-02-03T05:51:25ZengWileyCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/716138716138Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s DiseaseMariko Kaji0Takayuki Kishi1Takako Miyamae2Satoru Nagata3Hisashi Yamanaka4Satoshi Fujikawa5Department of Pediatrics, Tokyo Women’s Medical University, No. 8-1, Kawadacho, Shinjuku-ku, Tokyo 162-0054, JapanDepartment of Pediatrics, Tokyo Women’s Medical University, No. 8-1, Kawadacho, Shinjuku-ku, Tokyo 162-0054, JapanDepartment of Pediatrics, Tokyo Women’s Medical University, No. 8-1, Kawadacho, Shinjuku-ku, Tokyo 162-0054, JapanDepartment of Pediatrics, Tokyo Women’s Medical University, No. 8-1, Kawadacho, Shinjuku-ku, Tokyo 162-0054, JapanInstitute of Rheumatology, Tokyo Women’s Medical University, No. 10-22, Kawadacho, Shinjuku-ku, Tokyo 162-0054, JapanFujikawa Pediatrics Clinic, No. 7-29-2, Ooi, Shinagawa-ku, Tokyo 140-0014, JapanWe describe our experience with a juvenile patient who had refractory intestinal Behcet’s disease that responded to adalimumab, a fully humanized antibody against soluble TNF-α and its receptor. The patient, a 13-year-old girl, presented with oral aphthous ulcers, vulvar pain, and rashes on the lower extremities. She gradually developed a low-grade fever, abdominal pain, diarrhea, and hematochezia. Lower gastrointestinal endoscopy revealed ulcers in the terminal ileum, consistent with intestinal Behcet’s disease. Methylprednisolone pulse therapy was initiated, after which the symptoms transiently improved, but, during the corticosteroid taper, the abdominal pain recurred. The symptoms resolved soon after the administration of adalimumab. Of importance, the dose of corticosteroids was successfully reduced without exacerbation during 8 months of observation. This is the first reported case in which adalimumab was used for pediatric gastrointestinal Behcet’s disease. Adalimumab is a good choice for intestinal Behcet’s disease refractory to conventional treatment.http://dx.doi.org/10.1155/2015/716138 |
| spellingShingle | Mariko Kaji Takayuki Kishi Takako Miyamae Satoru Nagata Hisashi Yamanaka Satoshi Fujikawa Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease Case Reports in Rheumatology |
| title | Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease |
| title_full | Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease |
| title_fullStr | Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease |
| title_full_unstemmed | Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease |
| title_short | Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease |
| title_sort | efficacy of adalimumab in a girl with refractory intestinal behcet s disease |
| url | http://dx.doi.org/10.1155/2015/716138 |
| work_keys_str_mv | AT marikokaji efficacyofadalimumabinagirlwithrefractoryintestinalbehcetsdisease AT takayukikishi efficacyofadalimumabinagirlwithrefractoryintestinalbehcetsdisease AT takakomiyamae efficacyofadalimumabinagirlwithrefractoryintestinalbehcetsdisease AT satorunagata efficacyofadalimumabinagirlwithrefractoryintestinalbehcetsdisease AT hisashiyamanaka efficacyofadalimumabinagirlwithrefractoryintestinalbehcetsdisease AT satoshifujikawa efficacyofadalimumabinagirlwithrefractoryintestinalbehcetsdisease |