An innovative fungal-specific targeted next-generation sequencing method: analytical performance and a single-center prospective clinical study

An innovative fungal-specific targeted next-generation sequencing method: analytical performance and a single-center prospective clinical study

Abstract Background Invasive pulmonary fungal infections (IPFIs) pose significant diagnostic challenges, particularly in immunocompromised patients. Accurate and timely diagnosis is crucial to improve outcomes. While metagenomic next-generation sequencing (mNGS) is widely utilized, it is expensive a...

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Main Authors: Ruixuan Wang, Shitong Cheng, Wei Du, Fengshuo Sun, Yang Gao, Zheming Zhu, Chuan He, Jingjing Chen, Sufei Tian, Yunzhuo Chu, Gang Zhou, Hui Miao, Lifeng Li, Xiaolong Dong, Xiaoxu Han
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Invasive pulmonary fungal infections (IPFIs)
Targeted next-generation sequencing (tNGS)
Diagnostic performance
Additional diagnostic value
Online Access:https://doi.org/10.1186/s12967-025-06784-w
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https://doi.org/10.1186/s12967-025-06784-w

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