Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study
Aim. To investigate the role of maximum tumour diameter (D-max) reduction rate at CT examination in predicting histopathological tumour regression grade (TRG according to the Becker grade), after neoadjuvant chemotherapy (NAC), in patients with resectable advanced gastric cancer (AGC). Materials and...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/1794524 |
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| author | Maria Antonietta Mazzei Giulio Bagnacci Francesco Gentili Andrea Nigri Veronica Pelini Carla Vindigni Francesco Giuseppe Mazzei Gian Luca Baiocchi Frida Pittiani Paolo Morgagni Enrico Petrella Gianni Mura Beatrice Verdelli Maria Bencivenga Simone Giacopuzzi Daniele Marrelli Franco Roviello Luca Volterrani |
| author_facet | Maria Antonietta Mazzei Giulio Bagnacci Francesco Gentili Andrea Nigri Veronica Pelini Carla Vindigni Francesco Giuseppe Mazzei Gian Luca Baiocchi Frida Pittiani Paolo Morgagni Enrico Petrella Gianni Mura Beatrice Verdelli Maria Bencivenga Simone Giacopuzzi Daniele Marrelli Franco Roviello Luca Volterrani |
| author_sort | Maria Antonietta Mazzei |
| collection | DOAJ |
| description | Aim. To investigate the role of maximum tumour diameter (D-max) reduction rate at CT examination in predicting histopathological tumour regression grade (TRG according to the Becker grade), after neoadjuvant chemotherapy (NAC), in patients with resectable advanced gastric cancer (AGC). Materials and Methods. Eighty-six patients (53 M, mean age 62.1 years) with resectable AGC (≥T3 or N+), treated with NAC and radical surgery, were enrolled from 5 centres of the Italian Research Group for Gastric Cancer (GIRCG). Staging and restaging CT and histological results were retrospectively reviewed. CT examinations were contrast enhanced, and the stomach was previously distended. The D-max was measured using 2D software and compared with Becker TRG. Statistical data were obtained using “R” software. Results. The interobserver agreement was good/very good. Becker TRG was predicted by CT with a sensitivity and specificity, respectively, of 97.3% and 90.9% for Becker 1 (D-max reduction rate > 65.1%), 76.4% and 80% for Becker 3 (D-max reduction rate < 29.9%), and 70.8% and 83.9% for Becker 2. Correlation between radiological and histological D-max measurements was strongly confirmed by the correlation index (c.i.= 0.829). Conclusions. D-max reduction rate in AGC patients may be helpful as a simple and reproducible radiological index in predicting TRG after NAC. |
| format | Article |
| id | doaj-art-ab69ef97aad3431495a953d007e7cc92 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ab69ef97aad3431495a953d007e7cc922025-02-03T01:11:27ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/17945241794524Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG StudyMaria Antonietta Mazzei0Giulio Bagnacci1Francesco Gentili2Andrea Nigri3Veronica Pelini4Carla Vindigni5Francesco Giuseppe Mazzei6Gian Luca Baiocchi7Frida Pittiani8Paolo Morgagni9Enrico Petrella10Gianni Mura11Beatrice Verdelli12Maria Bencivenga13Simone Giacopuzzi14Daniele Marrelli15Franco Roviello16Luca Volterrani17Department of Medical, Surgical and Neuro Sciences, Unit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyDepartment of Medical, Surgical and Neuro Sciences, Unit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyDepartment of Medical, Surgical and Neuro Sciences, Unit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyFaculty of Statistics, Sapienza University of Rome, Roma, ItalyDepartment of Medical, Surgical and Neuro Sciences, Unit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyDepartment of Molecular and Developmental Medicine, Unit of Pathology, University of Siena, Siena, ItalyUnit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, Siena, ItalySurgical Clinic, Department of Experimental and Clinical Sciences, University of Brescia, Brescia, ItalyDepartment of Radiology, ASST Spedali Civili Brescia, Brescia, ItalyDepartment of General Surgery, Morgagni-Pierantoni Hospital, Forlì, ItalyRadiology Unit, Morgagni-Pierantoni Hospital, Forlì, ItalyDepartment of Surgery, Valdarno Hospital, Arezzo, ItalyDepartment of Radiology, Valdarno Hospital, Arezzo, ItalyGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Verona, ItalyGeneral and Upper GI Surgery Division, Department of Surgery, University of Verona, Verona, ItalyDepartment of Medical, Surgical and Neuro Sciences, Section of Surgery, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyDepartment of Medical, Surgical and Neuro Sciences, Section of Surgery, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyDepartment of Medical, Surgical and Neuro Sciences, Unit of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, ItalyAim. To investigate the role of maximum tumour diameter (D-max) reduction rate at CT examination in predicting histopathological tumour regression grade (TRG according to the Becker grade), after neoadjuvant chemotherapy (NAC), in patients with resectable advanced gastric cancer (AGC). Materials and Methods. Eighty-six patients (53 M, mean age 62.1 years) with resectable AGC (≥T3 or N+), treated with NAC and radical surgery, were enrolled from 5 centres of the Italian Research Group for Gastric Cancer (GIRCG). Staging and restaging CT and histological results were retrospectively reviewed. CT examinations were contrast enhanced, and the stomach was previously distended. The D-max was measured using 2D software and compared with Becker TRG. Statistical data were obtained using “R” software. Results. The interobserver agreement was good/very good. Becker TRG was predicted by CT with a sensitivity and specificity, respectively, of 97.3% and 90.9% for Becker 1 (D-max reduction rate > 65.1%), 76.4% and 80% for Becker 3 (D-max reduction rate < 29.9%), and 70.8% and 83.9% for Becker 2. Correlation between radiological and histological D-max measurements was strongly confirmed by the correlation index (c.i.= 0.829). Conclusions. D-max reduction rate in AGC patients may be helpful as a simple and reproducible radiological index in predicting TRG after NAC.http://dx.doi.org/10.1155/2018/1794524 |
| spellingShingle | Maria Antonietta Mazzei Giulio Bagnacci Francesco Gentili Andrea Nigri Veronica Pelini Carla Vindigni Francesco Giuseppe Mazzei Gian Luca Baiocchi Frida Pittiani Paolo Morgagni Enrico Petrella Gianni Mura Beatrice Verdelli Maria Bencivenga Simone Giacopuzzi Daniele Marrelli Franco Roviello Luca Volterrani Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study Gastroenterology Research and Practice |
| title | Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study |
| title_full | Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study |
| title_fullStr | Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study |
| title_full_unstemmed | Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study |
| title_short | Gastric Cancer Maximum Tumour Diameter Reduction Rate at CT Examination as a Radiological Index for Predicting Histopathological Regression after Neoadjuvant Treatment: A Multicentre GIRCG Study |
| title_sort | gastric cancer maximum tumour diameter reduction rate at ct examination as a radiological index for predicting histopathological regression after neoadjuvant treatment a multicentre gircg study |
| url | http://dx.doi.org/10.1155/2018/1794524 |
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