Ibuprofen for Ductus Arteriosus Months after Birth

Ibuprofen is a well-known agent used to treat patent ductus arteriosus in preterm neonates in the first days of life. In the current case report we illustrate the potential use of ibuprofen in two preterm neonates 60 and 88 days after birth, respectively. To our knowledge, this is the first report o...

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Main Authors: Odile Frauenfelder, Ingrid M. van Beynum, Irwin K. M. Reiss, Sinno H. P. Simons
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2016/2659389
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author Odile Frauenfelder
Ingrid M. van Beynum
Irwin K. M. Reiss
Sinno H. P. Simons
author_facet Odile Frauenfelder
Ingrid M. van Beynum
Irwin K. M. Reiss
Sinno H. P. Simons
author_sort Odile Frauenfelder
collection DOAJ
description Ibuprofen is a well-known agent used to treat patent ductus arteriosus in preterm neonates in the first days of life. In the current case report we illustrate the potential use of ibuprofen in two preterm neonates 60 and 88 days after birth, respectively. To our knowledge, this is the first report on the effects of ibuprofen on patent ductus arteriosus in preterm newborns after months of life. These cases suggest that the ductus arteriosus does not become refractory for ibuprofen after the first days of life. Late closure of the duct with ibuprofen might still improve the cardiorespiratory condition and prevent infants from surgical closure. Controlled trials are necessary to further study these findings.
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series Case Reports in Pediatrics
spelling doaj-art-ab62500a8c9b4ac393e3ba6cad5988b32025-02-03T01:08:48ZengWileyCase Reports in Pediatrics2090-68032090-68112016-01-01201610.1155/2016/26593892659389Ibuprofen for Ductus Arteriosus Months after BirthOdile Frauenfelder0Ingrid M. van Beynum1Irwin K. M. Reiss2Sinno H. P. Simons3Division of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, NetherlandsDivision of Pediatric Cardiology, Department of Pediatrics, Erasmus MC-Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, NetherlandsDivision of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, NetherlandsDivision of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, NetherlandsIbuprofen is a well-known agent used to treat patent ductus arteriosus in preterm neonates in the first days of life. In the current case report we illustrate the potential use of ibuprofen in two preterm neonates 60 and 88 days after birth, respectively. To our knowledge, this is the first report on the effects of ibuprofen on patent ductus arteriosus in preterm newborns after months of life. These cases suggest that the ductus arteriosus does not become refractory for ibuprofen after the first days of life. Late closure of the duct with ibuprofen might still improve the cardiorespiratory condition and prevent infants from surgical closure. Controlled trials are necessary to further study these findings.http://dx.doi.org/10.1155/2016/2659389
spellingShingle Odile Frauenfelder
Ingrid M. van Beynum
Irwin K. M. Reiss
Sinno H. P. Simons
Ibuprofen for Ductus Arteriosus Months after Birth
Case Reports in Pediatrics
title Ibuprofen for Ductus Arteriosus Months after Birth
title_full Ibuprofen for Ductus Arteriosus Months after Birth
title_fullStr Ibuprofen for Ductus Arteriosus Months after Birth
title_full_unstemmed Ibuprofen for Ductus Arteriosus Months after Birth
title_short Ibuprofen for Ductus Arteriosus Months after Birth
title_sort ibuprofen for ductus arteriosus months after birth
url http://dx.doi.org/10.1155/2016/2659389
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