Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition

Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition

Abstract Naringenin (NAR), a natural flavonoid, exerts anti-inflammatory and antioxidant pharmacology. However, the pharmacological mechanisms through which NAR prevents and treats intervertebral disc degeneration (IDD) remain unclear. We utilized bioinformatics, machine learning, and network pharma...

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Bibliographic Details
Main Authors: Xiaokai Tang, Junlong Zhong, Hao Luo, Faxin Zhou, Lixia Wang, Sijian Lin, Jiachao Xiong, Hao Lv, Zhenhai Zhou, Honggui Yu, Kai Cao
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Naringenin
Network pharmacology
Intervertebral disc degeneration
Aging and degeneration
Machine learning
Online Access:https://doi.org/10.1038/s41598-025-90909-0
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