Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review
Abstract Background Radiation-induced sarcoma (RIS) has a 10-year incidence of 0.2–0.27% and a poor prognosis, although the radiation should need for breast-conserving surgery. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6–3.7% of RIS. Case presentation A 43-...
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| Language: | English |
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Japan Surgical Society
2023-03-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-023-01629-4 |
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| author | Hideko Hoshina Kouichi Kubouchi Yutaka Tsutsumi Hiroyuki Takei |
| author_facet | Hideko Hoshina Kouichi Kubouchi Yutaka Tsutsumi Hiroyuki Takei |
| author_sort | Hideko Hoshina |
| collection | DOAJ |
| description | Abstract Background Radiation-induced sarcoma (RIS) has a 10-year incidence of 0.2–0.27% and a poor prognosis, although the radiation should need for breast-conserving surgery. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6–3.7% of RIS. Case presentation A 43-year-old woman with pT1N1M0 breast cancer underwent breast-conserving surgery, chemotherapy, radiation therapy 8 years ago, and continued hormonal therapy. She complained of a hard unprotruded mass palpated in her right upper outer quadrant of breast. Although we suspected local recurrence, core needle biopsy revealed atypical spindled tumor cells without mammary or epithelial markers. A diagnosis of fibrosarcoma was made via tumorectomy. She underwent additional enlarged surgery. Conclusions We report a rare case of fibrosarcoma in breast after breast-conserving surgery and radiation therapy. Fibrosarcoma after radiation therapy for breast cancer has been reported in 30 cases, including the present case. The dead and alive cases were not significantly different in terms of age, primary breast cancer, radiation dose, and following months. Patients with breast masses after radiation therapy should be suspected local recurrence and RIS. |
| format | Article |
| id | doaj-art-ab4c92ecc42e4a16a549efe8fa95d5bf |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-ab4c92ecc42e4a16a549efe8fa95d5bf2025-08-20T03:35:25ZengJapan Surgical SocietySurgical Case Reports2198-77932023-03-01911610.1186/s40792-023-01629-4Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature reviewHideko Hoshina0Kouichi Kubouchi1Yutaka Tsutsumi2Hiroyuki Takei3Department of Breast Surgery and Oncology, Nippon Medical SchoolDepartment of Breast Surgery, Kikuna Memorial HospitalDiagnostic Pathology ClinicDepartment of Breast Surgery and Oncology, Nippon Medical SchoolAbstract Background Radiation-induced sarcoma (RIS) has a 10-year incidence of 0.2–0.27% and a poor prognosis, although the radiation should need for breast-conserving surgery. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6–3.7% of RIS. Case presentation A 43-year-old woman with pT1N1M0 breast cancer underwent breast-conserving surgery, chemotherapy, radiation therapy 8 years ago, and continued hormonal therapy. She complained of a hard unprotruded mass palpated in her right upper outer quadrant of breast. Although we suspected local recurrence, core needle biopsy revealed atypical spindled tumor cells without mammary or epithelial markers. A diagnosis of fibrosarcoma was made via tumorectomy. She underwent additional enlarged surgery. Conclusions We report a rare case of fibrosarcoma in breast after breast-conserving surgery and radiation therapy. Fibrosarcoma after radiation therapy for breast cancer has been reported in 30 cases, including the present case. The dead and alive cases were not significantly different in terms of age, primary breast cancer, radiation dose, and following months. Patients with breast masses after radiation therapy should be suspected local recurrence and RIS.https://doi.org/10.1186/s40792-023-01629-4FibrosarcomaBreast cancerRadiation therapyRadiation-induced sarcomaRadiation-induced fibrosarcoma |
| spellingShingle | Hideko Hoshina Kouichi Kubouchi Yutaka Tsutsumi Hiroyuki Takei Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review Surgical Case Reports Fibrosarcoma Breast cancer Radiation therapy Radiation-induced sarcoma Radiation-induced fibrosarcoma |
| title | Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review |
| title_full | Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review |
| title_fullStr | Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review |
| title_full_unstemmed | Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review |
| title_short | Radiation-induced fibrosarcoma after breast-conserving therapy for breast cancer: a case report and literature review |
| title_sort | radiation induced fibrosarcoma after breast conserving therapy for breast cancer a case report and literature review |
| topic | Fibrosarcoma Breast cancer Radiation therapy Radiation-induced sarcoma Radiation-induced fibrosarcoma |
| url | https://doi.org/10.1186/s40792-023-01629-4 |
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