Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population
Background: Pterygium is a progressive fibrovascular tissue that affects the conjunctiva and cornea. The aim of the study was to compare the efficacy of Sub-conjunctival injection of Mitomycin C versus Bevacizumab in pterygium treatment focusing on their impact on recurrence rates to improve postop...
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| Format: | Article |
| Language: | English |
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ziauddin University
2025-01-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
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| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3290 |
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| author | Amber khalid Sharjeel Sultan Aveen Fatima Ayesha Khalid Maryam Shifa |
| author_facet | Amber khalid Sharjeel Sultan Aveen Fatima Ayesha Khalid Maryam Shifa |
| author_sort | Amber khalid |
| collection | DOAJ |
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Background: Pterygium is a progressive fibrovascular tissue that affects the conjunctiva and cornea. The aim of the study was to compare the efficacy of Sub-conjunctival injection of Mitomycin C versus Bevacizumab in pterygium treatment focusing on their impact on recurrence rates to improve postoperative outcomes.
Methods: The Randomized clinical trial was conducted in the Ophthalmology department of Ziauddin University over 8 months. 54 patients aged above 18 with grade 2 or 3 pterygium were divided into 2 groups of 27. Group A received a Subconjunctival injection of Mitomycin C while Group B received Bevacizumab. Patients were monitored at 1st and 3rd week post injection followed by pterygium excision 1 month later. The postoperative follow-up was conducted at the 1st, 3rd, and 6th months to assess improvement in symptoms and recurrence. The data was analyzed using SPSS version 23; the Chi-square test and Paired T-test were applied with a significance level of p < 0.05.
Results: The study analyzed data from 54 patients with pterygium, having a mean age of 42.03±8.23 years, with a male-to-female ratio of 3:1. The common symptoms were Redness (40.74%), itching (27.8%), and decreased visual acuity (31.4%). Post-injection outcome in terms of pterygium vascularity and thickness was better in group B. The recurrence rates at the 6th-month post excision were 1 (7.4%) and 3 (18.5%) in group B.
Conclusion: Mitomycin C as an adjuvant treatment demonstrates superior efficacy in reducing pterygium recurrence and improving postoperative vision, compared to Bevacizumab.
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| format | Article |
| id | doaj-art-ab48445b5a444fa094f6f4b8ba124e35 |
| institution | Kabale University |
| issn | 2313-7371 2308-2593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | ziauddin University |
| record_format | Article |
| series | Pakistan Journal of Medicine and Dentistry |
| spelling | doaj-art-ab48445b5a444fa094f6f4b8ba124e352025-01-19T20:18:28Zengziauddin UniversityPakistan Journal of Medicine and Dentistry2313-73712308-25932025-01-0114110.36283/ziun-pjmd14-1/009Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani PopulationAmber khalid0Sharjeel Sultan1Aveen Fatima2Ayesha Khalid3Maryam Shifa4Ziauddin University & Hospital ,Karachi, PakistanZiauddin University & Hospital, Karachi. Pakistan. Ziauddin University & Hospital ,Karachi, PakistanInstitute of Business Administration, Karachi, Pakistan. Ziauddin University & Hospital, Karachi, Pakistan. Background: Pterygium is a progressive fibrovascular tissue that affects the conjunctiva and cornea. The aim of the study was to compare the efficacy of Sub-conjunctival injection of Mitomycin C versus Bevacizumab in pterygium treatment focusing on their impact on recurrence rates to improve postoperative outcomes. Methods: The Randomized clinical trial was conducted in the Ophthalmology department of Ziauddin University over 8 months. 54 patients aged above 18 with grade 2 or 3 pterygium were divided into 2 groups of 27. Group A received a Subconjunctival injection of Mitomycin C while Group B received Bevacizumab. Patients were monitored at 1st and 3rd week post injection followed by pterygium excision 1 month later. The postoperative follow-up was conducted at the 1st, 3rd, and 6th months to assess improvement in symptoms and recurrence. The data was analyzed using SPSS version 23; the Chi-square test and Paired T-test were applied with a significance level of p < 0.05. Results: The study analyzed data from 54 patients with pterygium, having a mean age of 42.03±8.23 years, with a male-to-female ratio of 3:1. The common symptoms were Redness (40.74%), itching (27.8%), and decreased visual acuity (31.4%). Post-injection outcome in terms of pterygium vascularity and thickness was better in group B. The recurrence rates at the 6th-month post excision were 1 (7.4%) and 3 (18.5%) in group B. Conclusion: Mitomycin C as an adjuvant treatment demonstrates superior efficacy in reducing pterygium recurrence and improving postoperative vision, compared to Bevacizumab. https://ojs.zu.edu.pk/pjmd/article/view/3290PterygiumMitomycin C Bevacizumab |
| spellingShingle | Amber khalid Sharjeel Sultan Aveen Fatima Ayesha Khalid Maryam Shifa Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population Pakistan Journal of Medicine and Dentistry Pterygium Mitomycin C Bevacizumab |
| title | Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population |
| title_full | Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population |
| title_fullStr | Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population |
| title_full_unstemmed | Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population |
| title_short | Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population |
| title_sort | efficacy of sub conjunctival injection of mitomycin c versus bevacizumab in pterygium treatment pakistani population |
| topic | Pterygium Mitomycin C Bevacizumab |
| url | https://ojs.zu.edu.pk/pjmd/article/view/3290 |
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