Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis
The pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure. Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy. We assessed OA biomarkers and IL-1β-induced matrix metalloproteina...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2019/8143528 |
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| author | Gongbiao Lu Lin Du Jishou Lu Liuzhong Jin |
| author_facet | Gongbiao Lu Lin Du Jishou Lu Liuzhong Jin |
| author_sort | Gongbiao Lu |
| collection | DOAJ |
| description | The pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure. Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy. We assessed OA biomarkers and IL-1β-induced matrix metalloproteinase (MMP) expressions. Nanoparticles of 100 nm showed high drug loading of 28.6% (w/w) and extended drug release of 59% over 1 month. Our results demonstrated that nano treatment significantly improved IL-1β-induced cell viability of chondrocytes. Induction of MMP-9, MMP-13, and TNF-α was alleviated by nanoparticles. Furthermore, nano elevated the expression of osteopontin (OPN) and attenuated inducible nitric oxide synthase (iNOS) protein. Our data indicated the protective role of HA and APS-capsuled nanoparticles in OA treatment. |
| format | Article |
| id | doaj-art-ab46ff3de0e54cde88962528db91f050 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ab46ff3de0e54cde88962528db91f0502025-02-03T01:09:35ZengWileyInternational Journal of Polymer Science1687-94221687-94302019-01-01201910.1155/2019/81435288143528Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating OsteoarthritisGongbiao Lu0Lin Du1Jishou Lu2Liuzhong Jin3Department of Spine Surgery, Jining No. 1 People’s Hospital, Jining, Shandong 272011, ChinaSchool of Nursing, Jining Medical University, Jining 272013, ChinaDepartment of Spine Surgery, Jining No. 1 People’s Hospital, Jining, Shandong 272011, ChinaDepartment of Spine Surgery, Jining No. 1 People’s Hospital, Jining, Shandong 272011, ChinaThe pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure. Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy. We assessed OA biomarkers and IL-1β-induced matrix metalloproteinase (MMP) expressions. Nanoparticles of 100 nm showed high drug loading of 28.6% (w/w) and extended drug release of 59% over 1 month. Our results demonstrated that nano treatment significantly improved IL-1β-induced cell viability of chondrocytes. Induction of MMP-9, MMP-13, and TNF-α was alleviated by nanoparticles. Furthermore, nano elevated the expression of osteopontin (OPN) and attenuated inducible nitric oxide synthase (iNOS) protein. Our data indicated the protective role of HA and APS-capsuled nanoparticles in OA treatment.http://dx.doi.org/10.1155/2019/8143528 |
| spellingShingle | Gongbiao Lu Lin Du Jishou Lu Liuzhong Jin Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis International Journal of Polymer Science |
| title | Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis |
| title_full | Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis |
| title_fullStr | Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis |
| title_full_unstemmed | Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis |
| title_short | Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis |
| title_sort | nanoparticles containing hyaluronan acid and astragalus polysaccharides for treating osteoarthritis |
| url | http://dx.doi.org/10.1155/2019/8143528 |
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