Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension
Introduction Non-invasive tests that may improve clinical evaluation of pulmonary hypertension (PH) are needed. The purpose of this study was to assess the role of soluble ST2 (sST2) in patients with PH. Material and methods A total of 57 patients with chronic thromboembolic PH and 43 patients with...
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Termedia Publishing House
2020-09-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Soluble-ST2-protein-as-a-new-biomarker-in-patientswith-precapillary-pulmonary-hypertension,119710,0,2.html |
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| author | Marta Banaszkiewicz Arkadiusz Pietrasik Szymon Darocha Michał Piłka Michał Florczyk Anna Dobosiewicz Piotr Kędzierski Ewa Pędzich-Placha Janusz Kochman Grzegorz Opolski Adam Torbicki Marcin Kurzyna |
| author_facet | Marta Banaszkiewicz Arkadiusz Pietrasik Szymon Darocha Michał Piłka Michał Florczyk Anna Dobosiewicz Piotr Kędzierski Ewa Pędzich-Placha Janusz Kochman Grzegorz Opolski Adam Torbicki Marcin Kurzyna |
| author_sort | Marta Banaszkiewicz |
| collection | DOAJ |
| description | Introduction
Non-invasive tests that may improve clinical evaluation of pulmonary hypertension (PH) are needed. The purpose of this study was to assess the role of soluble ST2 (sST2) in patients with PH.
Material and methods
A total of 57 patients with chronic thromboembolic PH and 43 patients with idiopathic arterial PH were enrolled in this study. All patients were evaluated for World Health Organization (WHO) functional class (FC), N-terminal prohormone B-type natriuretic peptide (NT-proBNP), troponin T (TnT), and hemodynamics. Plasma sST2 was assessed by an immunofluorescent in vitro diagnostic assay. All patients were followed up from the date of blood sampling. The endpoint was all-cause death.
Results
The median sST2 concentration was 32.8 ng/ml (IQR: 21.6–48.5 ng/ml) in the whole study population. Significant differences were found between median sST2 in successive WHO FCs (FC II vs. FC III, p = 0.002; FC III vs. FC IV, p = 0.12; FC II vs. FC IV, p = 0.008). Significant correlations were found between sST2 and hemodynamic parameters: mean right atrial pressure (r = 0.56; p < 0.05), mean pulmonary artery pressure (r = 0.25; p < 0.05), cardiac index (r = –0.40; p < 0.05), pulmonary vascular resistance (r = 0.41; p < 0.05), and between sST2 and WHO FC (r = 0.36; p < 0.05), NT-proBNP (r = 0.55; p < 0.05), and TnT (r = 0.44; p < 0.05). sST2 concentration above the median was associated with worse clinical prognosis (p = 0.02, Kaplan-Meier).
Conclusions
sST2 seems to be a marker of poor clinical prognosis in patients with PH. |
| format | Article |
| id | doaj-art-ab41f3d8239f4d9aa9e1019fdb67b142 |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-ab41f3d8239f4d9aa9e1019fdb67b1422025-01-27T10:44:30ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512020-09-012051442145110.5114/aoms.2020.98635119710Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertensionMarta Banaszkiewicz0Arkadiusz Pietrasik1Szymon Darocha2Michał Piłka3Michał Florczyk4Anna Dobosiewicz5Piotr Kędzierski6Ewa Pędzich-Placha7Janusz Kochman8Grzegorz Opolski9Adam Torbicki10Marcin Kurzyna11Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandFirst Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandFirst Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, PolandFirst Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, PolandFirst Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, PolandIntroduction Non-invasive tests that may improve clinical evaluation of pulmonary hypertension (PH) are needed. The purpose of this study was to assess the role of soluble ST2 (sST2) in patients with PH. Material and methods A total of 57 patients with chronic thromboembolic PH and 43 patients with idiopathic arterial PH were enrolled in this study. All patients were evaluated for World Health Organization (WHO) functional class (FC), N-terminal prohormone B-type natriuretic peptide (NT-proBNP), troponin T (TnT), and hemodynamics. Plasma sST2 was assessed by an immunofluorescent in vitro diagnostic assay. All patients were followed up from the date of blood sampling. The endpoint was all-cause death. Results The median sST2 concentration was 32.8 ng/ml (IQR: 21.6–48.5 ng/ml) in the whole study population. Significant differences were found between median sST2 in successive WHO FCs (FC II vs. FC III, p = 0.002; FC III vs. FC IV, p = 0.12; FC II vs. FC IV, p = 0.008). Significant correlations were found between sST2 and hemodynamic parameters: mean right atrial pressure (r = 0.56; p < 0.05), mean pulmonary artery pressure (r = 0.25; p < 0.05), cardiac index (r = –0.40; p < 0.05), pulmonary vascular resistance (r = 0.41; p < 0.05), and between sST2 and WHO FC (r = 0.36; p < 0.05), NT-proBNP (r = 0.55; p < 0.05), and TnT (r = 0.44; p < 0.05). sST2 concentration above the median was associated with worse clinical prognosis (p = 0.02, Kaplan-Meier). Conclusions sST2 seems to be a marker of poor clinical prognosis in patients with PH.https://www.archivesofmedicalscience.com/Soluble-ST2-protein-as-a-new-biomarker-in-patientswith-precapillary-pulmonary-hypertension,119710,0,2.htmlpulmonary hypertensionsoluble st2biomarkersright heart failure |
| spellingShingle | Marta Banaszkiewicz Arkadiusz Pietrasik Szymon Darocha Michał Piłka Michał Florczyk Anna Dobosiewicz Piotr Kędzierski Ewa Pędzich-Placha Janusz Kochman Grzegorz Opolski Adam Torbicki Marcin Kurzyna Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension Archives of Medical Science pulmonary hypertension soluble st2 biomarkers right heart failure |
| title | Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension |
| title_full | Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension |
| title_fullStr | Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension |
| title_full_unstemmed | Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension |
| title_short | Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension |
| title_sort | soluble st2 protein as a new biomarker in patientswith precapillary pulmonary hypertension |
| topic | pulmonary hypertension soluble st2 biomarkers right heart failure |
| url | https://www.archivesofmedicalscience.com/Soluble-ST2-protein-as-a-new-biomarker-in-patientswith-precapillary-pulmonary-hypertension,119710,0,2.html |
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