A Review of Nonanesthetic Uses of Ketamine
Ketamine, a nonselective NMDA receptor antagonist, is used widely in medicine as an anesthetic agent. However, ketamine’s mechanisms of action lead to widespread physiological effects, some of which are now coming to the forefront of research for the treatment of diverse medical disorders. This pape...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/5798285 |
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| _version_ | 1832560688380248064 |
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| author | Abby Pribish Nicole Wood Arun Kalava |
| author_facet | Abby Pribish Nicole Wood Arun Kalava |
| author_sort | Abby Pribish |
| collection | DOAJ |
| description | Ketamine, a nonselective NMDA receptor antagonist, is used widely in medicine as an anesthetic agent. However, ketamine’s mechanisms of action lead to widespread physiological effects, some of which are now coming to the forefront of research for the treatment of diverse medical disorders. This paper aims at reviewing recent data on key nonanesthetic uses of ketamine in the current literature. MEDLINE, CINAHL, and Google Scholar databases were queried to find articles related to ketamine in the treatment of depression, pain syndromes including acute pain, chronic pain, and headache, neurologic applications including neuroprotection and seizures, and alcohol and substance use disorders. It can be concluded that ketamine has a potential role in the treatment of all of these conditions. However, research in this area is still in its early stages, and larger studies are required to evaluate ketamine’s efficacy for nonanesthetic purposes in the general population. |
| format | Article |
| id | doaj-art-ab3237535fe04fcfbf9dfca6da81edcb |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-ab3237535fe04fcfbf9dfca6da81edcb2025-02-03T01:26:56ZengWileyAnesthesiology Research and Practice1687-69621687-69702020-01-01202010.1155/2020/57982855798285A Review of Nonanesthetic Uses of KetamineAbby Pribish0Nicole Wood1Arun Kalava2Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USADepartment of Medicine, Cleveland Clinic, Cleveland, OH, USADepartment of Anesthesiology, University of Central Florida College of Medicine, Orlando, FL, USAKetamine, a nonselective NMDA receptor antagonist, is used widely in medicine as an anesthetic agent. However, ketamine’s mechanisms of action lead to widespread physiological effects, some of which are now coming to the forefront of research for the treatment of diverse medical disorders. This paper aims at reviewing recent data on key nonanesthetic uses of ketamine in the current literature. MEDLINE, CINAHL, and Google Scholar databases were queried to find articles related to ketamine in the treatment of depression, pain syndromes including acute pain, chronic pain, and headache, neurologic applications including neuroprotection and seizures, and alcohol and substance use disorders. It can be concluded that ketamine has a potential role in the treatment of all of these conditions. However, research in this area is still in its early stages, and larger studies are required to evaluate ketamine’s efficacy for nonanesthetic purposes in the general population.http://dx.doi.org/10.1155/2020/5798285 |
| spellingShingle | Abby Pribish Nicole Wood Arun Kalava A Review of Nonanesthetic Uses of Ketamine Anesthesiology Research and Practice |
| title | A Review of Nonanesthetic Uses of Ketamine |
| title_full | A Review of Nonanesthetic Uses of Ketamine |
| title_fullStr | A Review of Nonanesthetic Uses of Ketamine |
| title_full_unstemmed | A Review of Nonanesthetic Uses of Ketamine |
| title_short | A Review of Nonanesthetic Uses of Ketamine |
| title_sort | review of nonanesthetic uses of ketamine |
| url | http://dx.doi.org/10.1155/2020/5798285 |
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